Protein Structure Modeling with MODELLER View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2008

AUTHORS

Narayanan Eswar , David Eramian , Ben Webb , Min-Yi Shen , Andrej Sali

ABSTRACT

Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protcols has resulted in models of useful accuracy for domains in more than half of all known protein sequences. More... »

PAGES

145-159

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-60327-058-8_8

DOI

http://dx.doi.org/10.1007/978-1-60327-058-8_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037858536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18542861


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