Single Base Extension in Multiplex Blood Group Genotyping View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Gregory A Denomme

ABSTRACT

Transfusion recipients who become alloimmunized to blood group antigens require antigen-negative blood to limit adverse transfusion reactions. An alternative strategy to phenotyping blood is to assay genomic DNA for the associated single nucleotide polymorphisms (SNPs). A multiplex PCR coupled with a single base oligonucleotide extension assay using genomic DNA can identify SNPs related to D, C/c, E/e, S/s, K/k, Kp(a/b), Fy(a/b), Fy0 (-33 promoter silencing polymorphism), Jk(a/b), Di(a/b), and HPA-1a/b. Using this technology, individual SNP call rates vary from 98 to 100%. The platform has the capacity to genotype thousands of samples per day. The suite of SNPs provides rapid data for both blood donors and transfusion recipients and is poised to change whose blood is provided for potential transfusion recipients. The potential to dramatically lower the incidence of alloimmunization and to avoid serious hemolytic complications of transfusions can be realized with the implementation of this technology. More... »

PAGES

15-24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-553-4_2

DOI

http://dx.doi.org/10.1007/978-1-59745-553-4_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047235099

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18839101


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