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Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Jaina Mistry , Robert Finn

ABSTRACT

The constant deluge of genome sequencing data means that annotating, classifying, and comparing proteins or proteomes can seam like an endless task. Furthermore, discovering and accessing such data is fundamental to biologists. There are, however, databases that perform these tasks. Pfam, a protein families database, is one such database. In this chapter, the use of the web interface to Pfam and the resources provided (annotation, sequence alignments, phylogenetic trees, profile hidden Markov models [HMMs]) are described. The exploitation of tools for searching sequences against the library of Pfam HMMs, searching for domain combinations, searching by taxonomy, browsing proteomes, and comparing proteomes are outlined in detail. More... »

PAGES

43-58

References to SciGraph publications

  • 1992-06. One thousand families for the molecular biologist in NATURE
  • 2004-10. What is a hidden Markov model? in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-59745-515-2_4

    DOI

    http://dx.doi.org/10.1007/978-1-59745-515-2_4

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18025685


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