Cryopreservation of Allogeneic Stem Cell Products View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009-11-27

AUTHORS

Noelle V. Frey , Steven C. Goldstein

ABSTRACT

Donor stem cells for allogeneic transplant are traditionally collected and transfused “fresh” into the recipient on the day of transplant. Alternatively, donor stem cells can be collected in advance and cryopreserved until needed. Due to historical momentum and concerns that the cryopreservation and thawing process may damage the graft and worsen clinical outcomes, most institutions favor the former approach. The use of cryopreserved grafts has, therefore, traditionally been reserved for extreme circumstances of questionable donor reliability or availability. This trend is, however, slowly changing as some individual centers are favoring the use of frozen grafts in their related donor transplants due to increased ease of transplant coordination. Similarly, The National Marrow Donor Program (NMDP), which authorizes the collection of all cryopreserved unrelated grafts, has noticed an increasing trend in the use of frozen stem cell products. The total of cryopreserved stem cell grafts, however, still represents less than 2% of all unrelated products (R King; NMDP, personal communication). More... »

PAGES

427-439

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-478-0_24

DOI

http://dx.doi.org/10.1007/978-1-59745-478-0_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032524553


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