Single Nucleotide Polymorphisms and DNA Methylation Analysis Using Pyrosequencing Methods View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Jinsheng Yu , Sharon Marsh

ABSTRACT

The data generated from the Human Genome Project has led to an explosion of technology for low-, medium-, and high-throughput genotyping methods. Pyrosequencing is a genotyping assay based on sequencing by synthesis. Short runs of sequence around each polymorphism are generated, allowing for internal controls for each sample. Pyrosequencing can also be used to identify triallelic, indel, and short-repeat polymorphisms, as well as determining allele percentages for DNA methylation or pooled sample assessment. Assays details for pyrosequencing of clinically relevant polymorphisms and DNA methylations are described in this chapter. More... »

PAGES

119-140

References to SciGraph publications

Book

TITLE

Biomarker Methods in Drug Discovery and Development

ISBN

978-1-934115-23-7
978-1-59745-463-6

From Grant

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-463-6_6

DOI

http://dx.doi.org/10.1007/978-1-59745-463-6_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032498747


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