Impact of Clade Diversity on Neuropsychological Outcomes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2009

AUTHORS

Robert Paul , Ned Sacktor , Lucette Cysique , Bruce Brew , Victor Valcour

ABSTRACT

As described by Thomson in Chap. 13, it is possible that the different clade subtypes exhibit unique biological characteristics that lead to differential levels of vulnerability within the CNS. For example, differences may exist across clades in specific protein binding sites and binding characteristics, replicative capacity (2), and possibly in the development of treatment resistance (3, 4), though much more work is needed in this area. Evidence of faster disease progression among individuals in Africa infected with clade D virus offers yet additional evidence that the viral clades may exert unique biological impact on body systems (5) . Yet the nature and direction of these differences, particularly in terms of the brain, are not well described and in some cases they have been inconsistently described. More... »

PAGES

319-329

Book

TITLE

HIV and the Brain

ISBN

978-1-934115-08-4
978-1-59745-434-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-434-6_15

DOI

http://dx.doi.org/10.1007/978-1-59745-434-6_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048088296


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