Application of Stoichiometric and Kinetic Analyses to Characterize Cell Growth and Product Formation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Derek Adams , Rashmi Korke , Wei-Shou Hu

ABSTRACT

Stoichiometric and kinetic analyses are critical tools for developing efficient processes for the production of animal cell culture products such as therapeutic proteins or vaccines. This chapter describes the common analytical methods for quantifying animal cell growth and metabolism. It also presents sample calculations to illustrate the utility and limitations of various analytical methods. The application of calculated stoichiometric and kinetic parameters in mathematical models is also discussed. Hence, this chapter provides the basic tools for obtaining quantitative description of current cell culture state as well as applying the information for process optimization. More... »

PAGES

269-284

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-399-8_12

DOI

http://dx.doi.org/10.1007/978-1-59745-399-8_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015545137


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