Nucleic Acid Therapies for Cancer Treatment View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008-01-01

AUTHORS

Dan T. Vogl , Alan M. Gewirtz

ABSTRACT

A better understanding of the biochemical pathways mediating tumor growth and progression has provided a new set of targets for therapeutic intervention. The ability to target highly specific segments of genetic material using oligonucleotide probes has been the subject of nucleic acid based therapy and is being applied to a variety of human diseases, including cancer. This chapter will discuss the various strategies utilizing nucleic acids for inhibiting gene transcription and translation with a major focus on RNAi and antisense oligodeoxynucleotides. Specific targets will be described and results of preliminary clinical trials reported. Future challenges in the clinical translation of nucleic acid treatments will also be described. More... »

PAGES

413-429

Book

TITLE

Molecular Targeting in Oncology

ISBN

978-1-58829-577-4
978-1-59745-337-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-337-0_17

DOI

http://dx.doi.org/10.1007/978-1-59745-337-0_17

DIMENSIONS

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