Aberrant Transcription Factors in AML View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Alan D. Friedman

ABSTRACT

Several transcription factors both play a central role in normal, hematopoiesis and are altered in subsets of acute myeloid leukemia (AML). CBF, c-Myb, MLL, HOXA9, WT1, and EVI-1 regulate stem/progenitor cell expansion, C/EBPα, PU.1, and RARα control myeloid development, and GATA-1 is required for erythroid and megakaryocytic development. Chromosomal translocations, point mutations, or indirect effects on expression perturb the normal activities of these factors in myeloid leukemias. The contributions these aberrant transcription factors make to the transformed phenotype are described in this chapter, following a review of the functions of their normal counterparts in hematopoiesis. Targeting transcription factors as a novel mode of AML therapy is also discussed. More... »

PAGES

27-42

References to SciGraph publications

  • 2000-05. Exogenous cdk4 overcomes reducedcdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF – a model for overcoming inhibition of proliferation by CBF oncoproteins in ONCOGENE
  • 2002-01. BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2 in NATURE GENETICS
  • 2002-05. Transcriptional regulation of granulocyte and monocyte development in ONCOGENE
  • 1998-02. Role of the histone deacetylase complex in acute promyelocytic leukaemia in NATURE
  • 2003-02. Transcriptional activation is a key function encoded by MLL fusion partners in LEUKEMIA
  • 1997-09. CBFβ-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells in ONCOGENE
  • 1996-02. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias in NATURE GENETICS
  • 2001-04. AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia in NATURE MEDICINE
  • 2001-09. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins in ONCOGENE
  • 2002-09. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome in NATURE GENETICS
  • 2005-06. CBFβ-SMMHC slows proliferation of primary murine and human myeloid progenitors in LEUKEMIA
  • 1998-07. The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3 in NATURE
  • 2000-03. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages in NATURE
  • 2004-06. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1 in NATURE GENETICS
  • 2003-12. Role of PML and the PML-nuclear body in the control of programmed cell death in ONCOGENE
  • 2004-07. Acute promyelocytic leukemia: PML/RARα and the leukemic stem cell in LEUKEMIA
  • 2002-02. Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia in LEUKEMIA
  • 1997-03. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene in NATURE GENETICS
  • 2003-05. An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation in LEUKEMIA
  • 2001-10. Translocations of the RARα gene in acute promyelocytic leukemia in ONCOGENE
  • 1999. True in LEUKEMIA
  • 1996-02. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia in NATURE GENETICS
  • 2004-01. C/EBPαp30, a myeloid leukemia oncoprotein, limits G-CSF receptor expression but not terminal granulopoiesis via site-selective inhibition of C/EBP DNA binding in ONCOGENE
  • 1999-10. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia in NATURE GENETICS
  • 2002-07. The t(8;21) fusion protein, AML1–ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia in NATURE MEDICINE
  • 1999. True in LEUKEMIA
  • 2005-09. Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP in ONCOGENE
  • 1998-02. Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL in NATURE GENETICS
  • 2003-10. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor in NATURE IMMUNOLOGY
  • 2001-03. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia in NATURE GENETICS
  • 2004-06. Epigenetic regulation of tumor suppressors in t(8:21)-containing AML in ANNALS OF HEMATOLOGY
  • Book

    TITLE

    Acute Myelogenous Leukemia

    ISBN

    978-1-58829-621-4
    978-1-59745-322-6

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-59745-322-6_2

    DOI

    http://dx.doi.org/10.1007/978-1-59745-322-6_2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032350778


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