Heparin Anticoagulation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2007

AUTHORS

Graham F. Pineo , Russell D. Hull

ABSTRACT

In the initial treatment of patients presenting with acute pulmonary embolism (PE), anticoagulation is based either on unfractionated heparin (UFH) by continuous intravenous infusion and activated partial thromboplastin time monitoring, or on low-molecular-weight heparin (LMWH) given by once- or twice-daily subcutaneous injections. There have been several studies comparing the use of UFH and LMWH for the treatment of deep vein thrombosis (DVT), all demonstrating that LMWH is at least as effective and safe as UFH by continuous intravenous infusion. Fewer studies have compared the use of UFH and LMWH for the treatment of acute PE, but the evidence is that, as in DVT, LMWH is equally effective and safe compared to UFH. Furthermore, LMWH offers the convenience of out-of-hospital treatment for hemodynamically stable patients with nonmassive PE without the need for laboratory monitoring. Therefore, in the recent guidelines of the American College of Chest Physicians, either LMWH or UFH is recommended for the initial treatment of venous thromboembolism. In patients with advanced renal insufficiency, the recommendation is to use UFH rather the LMWH. More... »

PAGES

111-124

Book

TITLE

Management of Acute Pulmonary Embolism

ISBN

978-1-58829-644-3
978-1-59745-287-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-287-8_9

DOI

http://dx.doi.org/10.1007/978-1-59745-287-8_9

DIMENSIONS

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