Triplex-Mediated Gene Modification View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Erica B. Schleifman , Joanna Y. Chin , Peter M. Glazer

ABSTRACT

Gene targeting with DNA-binding molecules such as triplex-forming oligonucleotides or peptide nucleic acids can be utilized to direct mutagenesis or induce recombination site-specifically. In this chapter, several detailed protocols are described for the design and use of triplex-forming molecules to bind and mediate gene modification at specific chromosomal targets. Target site identification, binding molecule design, as well as various methods to test binding and assess gene modification are described. More... »

PAGES

175-190

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-232-8_13

DOI

http://dx.doi.org/10.1007/978-1-59745-232-8_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035082448

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18370076


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