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Ontology type: schema:Chapter     


Chapter Info

DATE

2006

AUTHORS

Shaoqi Rao , Qing K. Wang

ABSTRACT

A complex disease trait refers to a phenotype that does not follow simple Mendelian segregation attributable to a single gene locus, but instead may be caused by multiple disease loci, their interactions, polygenic inheritance, and environmental effects. Most cardiovascular disorders are thought to have a polygenic basis with complex interactions with environmental factors. A gene that increases or decreases the risk to a complex cardiovascular disease (susceptibility gene) can now be mapped to a specific chromosomal region by model-free linkage analysis, and follow-up molecular genetic studies can identify the specific gene at the locus. This chapter describes a protocol for model-free linkage analysis of a complex trait, as implemented in the popular genetic analysis software-SAGE. In particular, the Haseman-Elston sib-pair regression method is introduced and implemented with examples to demonstrate how to identify susceptibility loci for complex traits. More... »

PAGES

61-89

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59745-159-8_6

DOI

http://dx.doi.org/10.1007/978-1-59745-159-8_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013323876

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17071990


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