2008
AUTHORSDong-Hai Xiong , Jian-Feng Liu , Yan-Fang Guo , Yan Guo , Tie-Lin Yang , Hui Jiang , Yuan Chen , Fang Yang , Robert R Recker , Hong-Wen Deng
ABSTRACTThis chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping. Multiple traits and interaction analysis are also outlined. The application of modern genomic approaches, which mainly exploit the microarray technology, into QTL mapping was detailed. The latter are very recent protocols and are less developed than linkage and association methods at present. The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems. More... »
PAGES203-235
Osteoporosis
ISBN
978-1-58829-828-7
978-1-59745-104-8
http://scigraph.springernature.com/pub.10.1007/978-1-59745-104-8_16
DOIhttp://dx.doi.org/10.1007/978-1-59745-104-8_16
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18463822
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