Isolated Limb Perfusion for Malignant Melanoma and Soft Tissue Sarcoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000

AUTHORS

Joseph M. Klausner , Dina Lev-Chelouche , Subhi Abu-Abeid , Mordechai Gutman

ABSTRACT

In 1958, Creech et al. (1) introduced a novel method of drug delivery in advanced cancer, and named it isolated limb perfusion (ILP). The idea was to use the newly invented technique of cardiopulmonary bypass, which at that time had paved the way for open-heart surgery, in regional chemotherapy. They described a surgical method of exposing the major blood vessels of an extremity, providing its temporary isolation, and permitting perfusion of that extremity via the heart-lung machine, utilizing high doses of chemotherapeutic drugs. It would be possible to obtain high tissue concentrations of the drug with minimal systemic exposure and complications. Following the observation that heat on its own has antineoplastic properties (2), in 1969, Stehlin (3) modified the technique to include hyperthermia. Since then, ILP with melphalan, more than any other drug, has been widely recognized as the standard treatment strategy for advanced extremity melanoma. More... »

PAGES

57-85

Book

TITLE

Regional Chemotherapy

ISBN

978-1-4684-9697-0
978-1-59259-219-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-59259-219-7_5

DOI

http://dx.doi.org/10.1007/978-1-59259-219-7_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052065695


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