Production of Recombinant Trypanosoma cruzi Antigens in Leishmania tarentolae. View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2019

AUTHORS

María José Ferrer , Diana Patricia Wehrendt , Mariana Bonilla , Marcelo Alberto Comini , María Teresa Tellez-Iñón , Mariana Potenza

ABSTRACT

Trypanosomatids are unicellular organisms that colonize a wide diversity of environments and hosts. For instance, Trypanosoma cruzi is a human pathogen responsible for Chagas diseases, while Leishmania tarentolae infects amphibians and became a biotechnological tool suitable for recombinant protein expression. T. cruzi antigens are needed for the development of improved epitope-based methods for diagnosis and treatment of Chagas disease. Molecular cloning for the production of recombinant proteins offers the possibility to obtain T. cruzi antigens at high yield and purity. L. tarentolae appears as the ideal expression host to obtain recombinant T. cruzi antigens with a structure and posttranslational modifications typical of trypanosomatids. In this chapter, we present a protocol for the analytical to mid-scale production of recombinant T. cruzi antigens, using L. tarentolae as expression host (LEXSY® inducible system). More... »

PAGES

105-118

References to SciGraph publications

Book

TITLE

T. cruzi Infection

ISBN

978-1-4939-9147-1
978-1-4939-9148-8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-9148-8_8

DOI

http://dx.doi.org/10.1007/978-1-4939-9148-8_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112730815

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30868522


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