Models of Prostate Cancer Bone Metastasis. View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2019

AUTHORS

Sun Hee Park , Matthew Robert Eber , Yusuke Shiozawa

ABSTRACT

More than 80% of patients with advanced prostate cancer (PCa) experience bone metastasis, which negatively impacts overall survival and patient quality of life. Various mouse models have been used to study the mechanisms of bone metastasis over the years; however, there is currently no model that fully recapitulates what happens in humans because bone metastasis rarely occurs in spontaneous PCa mouse models. Nevertheless, animal models of bone metastasis using several different tumor inoculation routes have been developed to help study bone metastatic progression, which occurs particularly in late-stage PCa patients. This chapter describes the protocols commonly used to develop models of bone metastatic cancer in mice using different percutaneous injection methods (Intracardiac and Intraosseous). These models are useful for understanding the molecular mechanisms of bone metastatic progression, including tumor tissue tropism and tumor growth within the bone marrow microenvironment. Better understanding of the mechanisms involved in these processes will clearly lead to the development of new therapeutic strategies for PCa patients with bone metastases. More... »

PAGES

295-308

Book

TITLE

Bone Research Protocols

ISBN

978-1-4939-8996-6
978-1-4939-8997-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-8997-3_16

DOI

http://dx.doi.org/10.1007/978-1-4939-8997-3_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111980802

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30729472


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141 https://www.grid.ac/institutes/grid.412860.9 schema:alternateName Wake Forest Baptist Medical Center
142 schema:name Department of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
143 Department of Cancer Biology and Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC, USA. yshiozaw@wakehealth.edu.
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