Anti-factor H Autoantibodies Assay by ELISA View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-12-12

AUTHORS

Marie Sénant , Marie-Agnes Dragon-Durey

ABSTRACT

The complement system is a part of the immune system implicated in host defense against pathogens and damaged cells and Factor H is the main regulatory protein of this powerful enzymatic cascade. Autoantibodies directed against Factor H (anti-FH antibodies) are implicated in different pathologies mainly atypical hemolytic and uremic syndrome and C3 glomerulopathies. The detection and quantification of these autoantibodies are crucial for the clinical management of the patients.Anti-Factor H antibodies are detected and quantified by an ELISA assay. The aim of this chapter is to describe the procedure to determine anti-FH autoantibodies and to provide information about their biological significance. More... »

PAGES

191-196

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-8949-2_15

DOI

http://dx.doi.org/10.1007/978-1-4939-8949-2_15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110534010

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30539578


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