Autophagy Pathway Mapping to Elucidate the Function of Novel Autophagy Regulators Identified by High-Throughput Screening. View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2019

AUTHORS

Martina Wirth , Sharon A Tooze

ABSTRACT

Autophagy is an evolutionarily conserved degradative pathway, and the core autophagy machinery acts in a highly regulated, hierarchical manner to engulf cytoplasmic material in a double-membrane-bound organelle and deliver it to the lysosome. High-throughput screening approaches lead to the identification of novel autophagy regulators, and we describe an autophagy pathway mapping strategy to determine the stage of the autophagy pathway at which these novel candidate proteins function. More... »

PAGES

375-387

References to SciGraph publications

Book

TITLE

Autophagy

ISBN

978-1-4939-8872-3
978-1-4939-8873-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-8873-0_25

DOI

http://dx.doi.org/10.1007/978-1-4939-8873-0_25

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111100009

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30610711


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