Total Methionine Restriction Treatment of Cancer. View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2019

AUTHORS

Robert M Hoffman , Demetrius M Kokkinakis , Eugene P Frenkel

ABSTRACT

This chapter reviews how total methionine (MET) restriction (MR) of a human brain tumor xenograft, effected by the combination of recombinant L-methionine-α-deamino-γ-lyase (rMETase) and a MET-free diet, greatly potentiates standard chemotherapy for brain tumors in mouse models. The growth of human brain tumor Daoy, SWB77, and D-54 xenografts in nude mice was arrested after the depletion of mouse plasma methionine (MET) with a combination of an MR diet and rMETase and homocysteine to rescue normal cells and tissues. MET was depleted to below 5 μm by this treatment. MR for 10-12 days inhibited tumor growth, but did not prevent tumor regrowth after treatment cessation. A single dose of N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), which was ineffective alone, was administered at the end of the MR regimen, and caused a more than 80-day growth delay for Daoy and D-54 and a 20-day growth delay for SWB77. The total MR treatment regimens also increased the efficacy of temozolomide (TMZ) against the SWB77 xenograft when administered at the end of the MET regimen. More... »

PAGES

163-171

References to SciGraph publications

Book

TITLE

Methionine Dependence of Cancer and Aging

ISBN

978-1-4939-8795-5
978-1-4939-8796-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-8796-2_13

DOI

http://dx.doi.org/10.1007/978-1-4939-8796-2_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111933634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30725415


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