Rat Model of Cardiotoxic Drug-Induced Cardiomyopathy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-07-10

AUTHORS

Takehiro Nakahara , Takashi Tanimoto , Artiom D. Petrov , Kiyotake Ishikawa , H. William Strauss , Jagat Narula

ABSTRACT

Cardiotoxicity from cancer drugs remains a clinical problem. To find reliable markers of cardiotoxicity, animal models were proposed and potential new diagnostic markers have been actively investigated using these models. Here we describe our protocols, using male Sprague-Dawley rats, for inducing cardiomyopathy by single injection of high-dose doxorubicin (5–10 mg/kg) or multiple injections (2–4 times) of low-dose doxorubicin (2.5 mg/kg) with combined single injection of trastuzumab (10 mg/kg). The cardiotoxicity is evaluated by imaging modalities (echocardiography and nuclear imaging), serum troponin levels, and histopathological analyses. More... »

PAGES

221-232

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-8597-5_17

DOI

http://dx.doi.org/10.1007/978-1-4939-8597-5_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105416072

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29987823


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193 grid-institutes:grid.51462.34 schema:alternateName Molecular Imaging and Therapy Section, Memorial Sloan Kettering Cancer Center, New York, NY, USA
194 schema:name Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
195 Molecular Imaging and Therapy Section, Memorial Sloan Kettering Cancer Center, New York, NY, USA
196 rdf:type schema:Organization
197 grid-institutes:grid.59734.3c schema:alternateName Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
198 Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
199 schema:name Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
200 Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
201 rdf:type schema:Organization
 




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