Experimental and Computational Protocols for Studies of Cross-Seeding Amyloid Assemblies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018-05-10

AUTHORS

Baiping Ren , Rundong Hu , Mingzhen Zhang , Yonglan Liu , Lijian Xu , Binbo Jiang , Jie Ma , Buyong Ma , Ruth Nussinov , Jie Zheng

ABSTRACT

Alzheimer's disease (AD) and type 2 diabetes (T2D) are two common protein aggregation diseases. Compelling evidence has shown a link between AD and T2D, which may derive from interspecies cross-sequence interactions between amyloid-β peptide (Aβ), associated with AD, and human islet amyloid polypeptide (hIAPP), associated with T2D. Herein, we present experimental and computational protocols and tools to study the aggregate structures and kinetics, conformational conversion, and molecular interactions of Aβ-hIAPP mixtures. These protocols could be generally applied to other cross-seeding behaviors of amyloid peptides. More... »

PAGES

429-447

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-7811-3_27

DOI

http://dx.doi.org/10.1007/978-1-4939-7811-3_27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103901753

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29744852


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