Ontology type: schema:Chapter
2018
AUTHORSTsukasa Kusakizako , Yoshiki Tanaka , Christopher J. Hipolito , Hiroaki Suga , Osamu Nureki
ABSTRACTMultidrug exporters expressed in pathogens efflux substrate drugs such as antibiotics, and thus, the development of inhibitors against them has eagerly been anticipated. Furthermore, the crystal structures of multidrug exporters with their inhibitors provide novel insights into the inhibitory mechanism and the development of more specific and effective inhibitors. We previously reported the complex structures of the Multidrug And Toxic compound Extrusion (MATE)-type multidrug exporter with the macrocyclic peptides, which inhibit the efflux of substrates by the MATE-type multidrug exporter (Tanaka et al., Nature 496:247-251, 2013). In this chapter, we describe methodologies of the screening and synthesis of macrocyclic peptides as inhibitors, as well as the purification, crystallization, and structure determination of the complexes of the MATE-type multidrug exporter with its inhibitors. More... »
PAGES37-57
Bacterial Multidrug Exporters
ISBN
978-1-4939-7452-8
978-1-4939-7454-2
http://scigraph.springernature.com/pub.10.1007/978-1-4939-7454-2_3
DOIhttp://dx.doi.org/10.1007/978-1-4939-7454-2_3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092971001
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29177824
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Archaeal Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crystallography, X-Ray",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Evaluation, Preclinical",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Molecular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Organic Cation Transport Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peptides, Cyclic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Conformation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pyrococcus furiosus",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"The University of Tokyo"
],
"type": "Organization"
},
"familyName": "Kusakizako",
"givenName": "Tsukasa",
"id": "sg:person.01137642207.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137642207.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Nara Institute of Science and Technology",
"id": "https://www.grid.ac/institutes/grid.260493.a",
"name": [
"Nara Institute of Science and Technology"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Yoshiki",
"id": "sg:person.01367623672.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367623672.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tsukuba",
"id": "https://www.grid.ac/institutes/grid.20515.33",
"name": [
"The University of Tokyo",
"University of Tsukuba"
],
"type": "Organization"
},
"familyName": "Hipolito",
"givenName": "Christopher J.",
"id": "sg:person.0576407632.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576407632.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"The University of Tokyo"
],
"type": "Organization"
},
"familyName": "Suga",
"givenName": "Hiroaki",
"id": "sg:person.012476173541.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012476173541.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"The University of Tokyo"
],
"type": "Organization"
},
"familyName": "Nureki",
"givenName": "Osamu",
"id": "sg:person.01043223704.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043223704.15"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1107/s0907444910007493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000235100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444910007493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000235100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/aac.49.5.1865-1871.2005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002319938"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003844296",
"https://doi.org/10.1038/nature12014"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.str.2012.06.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009108816"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.str.2012.06.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009108816"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncomms8995",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012049543",
"https://doi.org/10.1038/ncomms8995"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0021889807021206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012753217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/molecules180910514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013269892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/molecules180910514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013269892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1219901110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013864174"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/0471140864.ps0209s50",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019018541"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2958.1999.01162.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019649302"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909052925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020777046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909052925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020777046"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2009.31",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021131005",
"https://doi.org/10.1038/nprot.2009.31"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2009.31",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021131005",
"https://doi.org/10.1038/nprot.2009.31"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jb.186.1.262-265.2004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022633816"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444911056058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026847319"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2011.331",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031634563",
"https://doi.org/10.1038/nprot.2011.331"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/90802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032863741",
"https://doi.org/10.1038/90802"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmicrobiol.2015.9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034126623",
"https://doi.org/10.1038/nmicrobiol.2015.9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb.2687",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035712479",
"https://doi.org/10.1038/nsmb.2687"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.94.23.12297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036127838"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0909049509041168",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036674335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0909049509041168",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036674335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.str.2006.01.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040537865"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040864737",
"https://doi.org/10.1038/nature05076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040864737",
"https://doi.org/10.1038/nature05076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040864737",
"https://doi.org/10.1038/nature05076"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-5793(97)01026-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041413209"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.25.14532",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041570961"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ymeth.2005.04.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042126377"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ymeth.2005.04.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042126377"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ymeth.2005.04.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042126377"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042208726",
"https://doi.org/10.1038/nature09408"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042208726",
"https://doi.org/10.1038/nature09408"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1742-6596/425/1/012002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044156712"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12300",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045085615",
"https://doi.org/10.1038/nature12300"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05155",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046978650",
"https://doi.org/10.1038/nature05155"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05155",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046978650",
"https://doi.org/10.1038/nature05155"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05155",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046978650",
"https://doi.org/10.1038/nature05155"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/aac.49.5.1857-1864.2005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048822420"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0021889808007966",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048952238"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/1-59745-266-1:215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052201743",
"https://doi.org/10.1385/1-59745-266-1:215"
],
"type": "CreativeWork"
}
],
"datePublished": "2018",
"datePublishedReg": "2018-01-01",
"description": "Multidrug exporters expressed in pathogens efflux substrate drugs such as antibiotics, and thus, the development of inhibitors against them has eagerly been anticipated. Furthermore, the crystal structures of multidrug exporters with their inhibitors provide novel insights into the inhibitory mechanism and the development of more specific and effective inhibitors. We previously reported the complex structures of the Multidrug And Toxic compound Extrusion (MATE)-type multidrug exporter with the macrocyclic peptides, which inhibit the efflux of substrates by the MATE-type multidrug exporter (Tanaka et al., Nature 496:247-251, 2013). In this chapter, we describe methodologies of the screening and synthesis of macrocyclic peptides as inhibitors, as well as the purification, crystallization, and structure determination of the complexes of the MATE-type multidrug exporter with its inhibitors.",
"editor": [
{
"familyName": "Yamaguchi",
"givenName": "Akihito",
"type": "Person"
},
{
"familyName": "Nishino",
"givenName": "Kunihiko",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-1-4939-7454-2_3",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-1-4939-7452-8",
"978-1-4939-7454-2"
],
"name": "Bacterial Multidrug Exporters",
"type": "Book"
},
"name": "Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors",
"pagination": "37-57",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-1-4939-7454-2_3"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"06dde93329db221d0fce1a63b6171009e64aa7ff37ed812fd71521be1e53a9b3"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092971001"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29177824"
]
}
],
"publisher": {
"location": "New York, NY",
"name": "Springer New York",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-1-4939-7454-2_3",
"https://app.dimensions.ai/details/publication/pub.1092971001"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-15T16:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000601.jsonl",
"type": "Chapter",
"url": "http://link.springer.com/10.1007/978-1-4939-7454-2_3"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7454-2_3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7454-2_3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7454-2_3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7454-2_3'
This table displays all metadata directly associated to this object as RDF triples.
249 TRIPLES
23 PREDICATES
68 URIs
29 LITERALS
17 BLANK NODES