GluNs Detection and Functions in Microglial Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Stéphane Peineau , Vincent Degos , Catherine Verney , Pierre Gressens

ABSTRACT

Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2) their cellular localization, (3) that the GluN are functional, and (4) the role of the functional GluN. The complete demonstration is performed by using mRNA detection technics, western blots, immunofluorescence, electrophysiology, calcium imaging, morphology studies, multiplex immunoassay together with conditional microglial Knock-Out mice and brain lesion models. More... »

PAGES

253-263

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-7321-7_14

DOI

http://dx.doi.org/10.1007/978-1-4939-7321-7_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091674752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28986878


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophysiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorescent Antibody Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoassay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microglia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, N-Methyl-D-Aspartate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Picardie Jules Verne", 
          "id": "https://www.grid.ac/institutes/grid.11162.35", 
          "name": [
            "University of Bristol", 
            "Universit\u00e9 Paris Diderot", 
            "Universit\u00e9 de Picardie Jules Verne"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peineau", 
        "givenName": "St\u00e9phane", 
        "id": "sg:person.0720004535.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720004535.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Universit\u00e9 Paris Diderot"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Degos", 
        "givenName": "Vincent", 
        "id": "sg:person.0636243456.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636243456.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "Universit\u00e9 Paris Diderot"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verney", 
        "givenName": "Catherine", 
        "id": "sg:person.01272430242.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272430242.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "University of Bristol", 
            "King\u2019s College, St Thomas\u2019 Campus"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gressens", 
        "givenName": "Pierre", 
        "id": "sg:person.0643134421.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jnr.10153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025879544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032889905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038631743", 
          "https://doi.org/10.1038/nprot.2006.83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038631743", 
          "https://doi.org/10.1038/nprot.2006.83"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017", 
    "datePublishedReg": "2017-01-01", 
    "description": "Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2) their cellular localization, (3) that the GluN are functional, and (4) the role of the functional GluN. The complete demonstration is performed by using mRNA detection technics, western blots, immunofluorescence, electrophysiology, calcium imaging, morphology studies, multiplex immunoassay together with conditional microglial Knock-Out mice and brain lesion models.", 
    "editor": [
      {
        "familyName": "Burnashev", 
        "givenName": "Nail", 
        "type": "Person"
      }, 
      {
        "familyName": "Szepetowski", 
        "givenName": "Pierre", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4939-7321-7_14", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4939-7320-0", 
        "978-1-4939-7321-7"
      ], 
      "name": "NMDA Receptors", 
      "type": "Book"
    }, 
    "name": "GluNs Detection and Functions in Microglial Cells", 
    "pagination": "253-263", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4939-7321-7_14"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "87d69e6ffab9e19c8c42bc286bff88d89f2fadcca25d759cb04218dbcb72722b"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091674752"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28986878"
        ]
      }
    ], 
    "publisher": {
      "location": "New York, NY", 
      "name": "Springer New York", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4939-7321-7_14", 
      "https://app.dimensions.ai/details/publication/pub.1091674752"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T23:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000475.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-4939-7321-7_14"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7321-7_14'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7321-7_14'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7321-7_14'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7321-7_14'


 

This table displays all metadata directly associated to this object as RDF triples.

150 TRIPLES      23 PREDICATES      40 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4939-7321-7_14 schema:about N04da82f97ed54d5a9392d7dd4f1ae87c
2 N576c531bb8f541bdac64497abf66692c
3 N5d60b7ceab5d476c98c16e7a3eb7a092
4 N67112e9dbc794affb1548df6969d0673
5 N89baee84fd6f469682f0762443b39f59
6 N8c80efe60d934a688aa5cca2a94ba51b
7 Na482dbf1a1c24a0594911db91427310c
8 Nba3acc21e1c84700acd8f2a47a9f5d69
9 Nc833159d27964581a32b3bacfee77bd1
10 anzsrc-for:11
11 anzsrc-for:1109
12 schema:author Nc5e13dc4b5ae470b99513aecfde2facb
13 schema:citation sg:pub.10.1038/nprot.2006.83
14 https://doi.org/10.1002/jnr.10153
15 https://doi.org/10.1172/jci119545
16 schema:datePublished 2017
17 schema:datePublishedReg 2017-01-01
18 schema:description Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2) their cellular localization, (3) that the GluN are functional, and (4) the role of the functional GluN. The complete demonstration is performed by using mRNA detection technics, western blots, immunofluorescence, electrophysiology, calcium imaging, morphology studies, multiplex immunoassay together with conditional microglial Knock-Out mice and brain lesion models.
19 schema:editor N60a9d3a6b791488bbdea07c35f26b04e
20 schema:genre chapter
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf N13d2e30e62164622958b9c07e1ed3bab
24 schema:name GluNs Detection and Functions in Microglial Cells
25 schema:pagination 253-263
26 schema:productId N1d8fb61f86614924ae6b9ea565bc315d
27 N6bf49fd3e5e548a3a3b5c05fef6adea5
28 Nb1b26a9a8e9842dcbf87b8f3a955d5ae
29 Nc232cf64716444a4b691369569ffd4c8
30 schema:publisher Nd9c9532587b84c0cab5b98f454468920
31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091674752
32 https://doi.org/10.1007/978-1-4939-7321-7_14
33 schema:sdDatePublished 2019-04-15T23:19
34 schema:sdLicense https://scigraph.springernature.com/explorer/license/
35 schema:sdPublisher Nc168b38d6d8243d586b738006e3750f4
36 schema:url http://link.springer.com/10.1007/978-1-4939-7321-7_14
37 sgo:license sg:explorer/license/
38 sgo:sdDataset chapters
39 rdf:type schema:Chapter
40 N04da82f97ed54d5a9392d7dd4f1ae87c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
41 schema:name Animals
42 rdf:type schema:DefinedTerm
43 N13d2e30e62164622958b9c07e1ed3bab schema:isbn 978-1-4939-7320-0
44 978-1-4939-7321-7
45 schema:name NMDA Receptors
46 rdf:type schema:Book
47 N1a98d8aee5a343dcb7cc2d961c454e5a rdf:first sg:person.01272430242.87
48 rdf:rest Na5afbe88bb77456b83d212c84d3bfeab
49 N1d8fb61f86614924ae6b9ea565bc315d schema:name readcube_id
50 schema:value 87d69e6ffab9e19c8c42bc286bff88d89f2fadcca25d759cb04218dbcb72722b
51 rdf:type schema:PropertyValue
52 N43e57515b7e34f69aa6b0026f547114c schema:familyName Szepetowski
53 schema:givenName Pierre
54 rdf:type schema:Person
55 N572dd064cbfe46b6a0241db299097b9f schema:familyName Burnashev
56 schema:givenName Nail
57 rdf:type schema:Person
58 N576c531bb8f541bdac64497abf66692c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Mice, Knockout
60 rdf:type schema:DefinedTerm
61 N5d60b7ceab5d476c98c16e7a3eb7a092 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Immunoassay
63 rdf:type schema:DefinedTerm
64 N60a9d3a6b791488bbdea07c35f26b04e rdf:first N572dd064cbfe46b6a0241db299097b9f
65 rdf:rest Nfaa1aacfd54a4e8183489102bc365ace
66 N643bd89ebf0f4741978f3e823f789777 rdf:first sg:person.0636243456.65
67 rdf:rest N1a98d8aee5a343dcb7cc2d961c454e5a
68 N67112e9dbc794affb1548df6969d0673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Electrophysiology
70 rdf:type schema:DefinedTerm
71 N6bf49fd3e5e548a3a3b5c05fef6adea5 schema:name pubmed_id
72 schema:value 28986878
73 rdf:type schema:PropertyValue
74 N89baee84fd6f469682f0762443b39f59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Brain
76 rdf:type schema:DefinedTerm
77 N8c80efe60d934a688aa5cca2a94ba51b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Microglia
79 rdf:type schema:DefinedTerm
80 Na482dbf1a1c24a0594911db91427310c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Receptors, N-Methyl-D-Aspartate
82 rdf:type schema:DefinedTerm
83 Na5afbe88bb77456b83d212c84d3bfeab rdf:first sg:person.0643134421.39
84 rdf:rest rdf:nil
85 Nb1b26a9a8e9842dcbf87b8f3a955d5ae schema:name doi
86 schema:value 10.1007/978-1-4939-7321-7_14
87 rdf:type schema:PropertyValue
88 Nba3acc21e1c84700acd8f2a47a9f5d69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Fluorescent Antibody Technique
90 rdf:type schema:DefinedTerm
91 Nc168b38d6d8243d586b738006e3750f4 schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 Nc232cf64716444a4b691369569ffd4c8 schema:name dimensions_id
94 schema:value pub.1091674752
95 rdf:type schema:PropertyValue
96 Nc5e13dc4b5ae470b99513aecfde2facb rdf:first sg:person.0720004535.51
97 rdf:rest N643bd89ebf0f4741978f3e823f789777
98 Nc833159d27964581a32b3bacfee77bd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Mice
100 rdf:type schema:DefinedTerm
101 Nd9c9532587b84c0cab5b98f454468920 schema:location New York, NY
102 schema:name Springer New York
103 rdf:type schema:Organisation
104 Nfaa1aacfd54a4e8183489102bc365ace rdf:first N43e57515b7e34f69aa6b0026f547114c
105 rdf:rest rdf:nil
106 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
107 schema:name Medical and Health Sciences
108 rdf:type schema:DefinedTerm
109 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
110 schema:name Neurosciences
111 rdf:type schema:DefinedTerm
112 sg:person.01272430242.87 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
113 schema:familyName Verney
114 schema:givenName Catherine
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272430242.87
116 rdf:type schema:Person
117 sg:person.0636243456.65 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
118 schema:familyName Degos
119 schema:givenName Vincent
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636243456.65
121 rdf:type schema:Person
122 sg:person.0643134421.39 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
123 schema:familyName Gressens
124 schema:givenName Pierre
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39
126 rdf:type schema:Person
127 sg:person.0720004535.51 schema:affiliation https://www.grid.ac/institutes/grid.11162.35
128 schema:familyName Peineau
129 schema:givenName Stéphane
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720004535.51
131 rdf:type schema:Person
132 sg:pub.10.1038/nprot.2006.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038631743
133 https://doi.org/10.1038/nprot.2006.83
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1002/jnr.10153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025879544
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1172/jci119545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032889905
138 rdf:type schema:CreativeWork
139 https://www.grid.ac/institutes/grid.11162.35 schema:alternateName University of Picardie Jules Verne
140 schema:name University of Bristol
141 Université Paris Diderot
142 Université de Picardie Jules Verne
143 rdf:type schema:Organization
144 https://www.grid.ac/institutes/grid.5337.2 schema:alternateName University of Bristol
145 schema:name King’s College, St Thomas’ Campus
146 University of Bristol
147 rdf:type schema:Organization
148 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
149 schema:name Université Paris Diderot
150 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...