GluNs Detection and Functions in Microglial Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-09-12

AUTHORS

Stéphane Peineau , Vincent Degos , Catherine Verney , Pierre Gressens

ABSTRACT

Proving endogenous GluN presence and functions in microglia require complementary steps to demonstrate (1) that GluN genes are transcripted and translated, (2) their cellular localization, (3) that the GluN are functional, and (4) the role of the functional GluN. The complete demonstration is performed by using mRNA detection technics, western blots, immunofluorescence, electrophysiology, calcium imaging, morphology studies, multiplex immunoassay together with conditional microglial Knock-Out mice and brain lesion models. More... »

PAGES

253-263

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-7321-7_14

DOI

http://dx.doi.org/10.1007/978-1-4939-7321-7_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091674752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28986878


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