Strategies to Develop Therapeutic N- and O-Hyperglycosylated Proteins View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2018

AUTHORS

Agustina Gugliotta , Natalia Ceaglio , Marina Etcheverrigaray , Ricardo Kratje , Marcos Oggero

ABSTRACT

Glycoengineering by N- and/or O-hyperglycosylation represents a procedure to introduce potential sites for adding N- and/or O-glycosyl structures to proteins with the aim of producing biotherapeutics with improved pharmacodynamic and pharmacokinetic properties. In this chapter, a detailed description of the steps routinely performed to generate new proteins having high content of N- and/or O-glycosyl moieties is carried out. The rational strategy involves the initial stage of designing N- and/or O-hyperglycosylated muteins to be expressed by mammalian cells and includes the upstream and downstream processing stages necessary to develop hyperglycosylated versions of the proteins of interest with the purpose of beginning the long road toward producing biobetters. More... »

PAGES

163-181

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-7312-5_13

DOI

http://dx.doi.org/10.1007/978-1-4939-7312-5_13

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091830953

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28921436


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