Assessing Structure–Function Relations in Mice Using the Forced Oscillation Technique and Quantitative Histology View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Harikrishnan Parameswaran , Béla Suki

ABSTRACT

The structure and function of the lung gradually becomes compromised during the progression of emphysema. In this chapter, we first describe how to assess and evaluate lung function using the forced oscillation technique. Next, we provide details on how to use the Flexivent system to measure respiratory mechanical parameters in mice. We also describe the outlines of how to set up a homemade forced oscillatory system and use it to measure respiratory mechanics. To characterize the structure from standard histological images, we describe a method that is highly sensitive to early emphysema. Correlating structural information such as equivalent alveolar diameter and its variance with respiratory elastance or compliance, provides structure-function relationships that can subsequently reveal novel mechanisms of emphysema progression or be used to track the effectiveness of treatment. More... »

PAGES

77-91

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-7163-3_8

DOI

http://dx.doi.org/10.1007/978-1-4939-7163-3_8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090910561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28752448


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