The “Sticky Patch” Model of Crystallization and Modification of Proteins for Enhanced Crystallizability View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2017

AUTHORS

Zygmunt S. Derewenda , Adam Godzik

ABSTRACT

Crystallization of macromolecules has long been perceived as a stochastic process, which cannot be predicted or controlled. This is consistent with another popular notion that the interactions of molecules within the crystal, i.e., crystal contacts, are essentially random and devoid of specific physicochemical features. In contrast, functionally relevant surfaces, such as oligomerization interfaces and specific protein-protein interaction sites, are under evolutionary pressures so their amino acid composition, structure, and topology are distinct. However, current theoretical and experimental studies are significantly changing our understanding of the nature of crystallization. The increasingly popular "sticky patch" model, derived from soft matter physics, describes crystallization as a process driven by interactions between select, specific surface patches, with properties thermodynamically favorable for cohesive interactions. Independent support for this model comes from various sources including structural studies and bioinformatics. Proteins that are recalcitrant to crystallization can be modified for enhanced crystallizability through chemical or mutational modification of their surface to effectively engineer "sticky patches" which would drive crystallization. Here, we discuss the current state of knowledge of the relationship between the microscopic properties of the target macromolecule and its crystallizability, focusing on the "sticky patch" model. We discuss state-of-the-art in silico methods that evaluate the propensity of a given target protein to form crystals based on these relationships, with the objective to design variants with modified molecular surface properties and enhanced crystallization propensity. We illustrate this discussion with specific cases where these approaches allowed to generate crystals suitable for structural analysis. More... »

PAGES

77-115

References to SciGraph publications

  • 2010-06. Enhanced crystal packing due to solvent reorganization through reductive methylation of lysine residues in oxidoreductase from Streptococcus pneumoniae in JOURNAL OF STRUCTURAL AND FUNCTIONAL GENOMICS
  • 2015-12. A common assembly module in injectisome and flagellar type III secretion sorting platforms in NATURE COMMUNICATIONS
  • 2014. DisMeta: A Meta Server for Construct Design and Optimization in STRUCTURAL GENOMICS
  • 2008-05-22. Gelation of particles with short-range attraction in NATURE
  • 1934-05. X-Ray Photographs of Crystalline Pepsin in NATURE
  • 1998-06. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody in NATURE
  • 1999-10. Structural genomics: beyond the Human Genome Project in NATURE GENETICS
  • 2015-12. Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling in CELL COMMUNICATION AND SIGNALING
  • 2015-05. Ion-activated attractive patches as a mechanism for controlled protein interactions in SCIENTIFIC REPORTS
  • 2009-10. Ubiquitin-binding domains — from structures to functions in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-12. In situ proteolysis for protein crystallization and structure determination in NATURE METHODS
  • 1995-12. Why protein crystals favour some space-groups over others in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-12. (NZ)CH...O Contacts assist crystallization of a ParB-like nuclease in BMC STRUCTURAL BIOLOGY
  • 1954-11. The Species Specificity of Myoglobin in NATURE
  • 2011-07. The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods in JOURNAL OF STRUCTURAL AND FUNCTIONAL GENOMICS
  • 2006-11. Three-dimensional structure of the KChIP1–Kv4.3 T1 complex reveals a cross-shaped octamer in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-03. Predicting protein crystallization propensity from protein sequence in JOURNAL OF STRUCTURAL AND FUNCTIONAL GENOMICS
  • 2000-10-01. Structural proteomics of an archaeon in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-10. Large-scale evaluation of protein reductive methylation for improving protein crystallization in NATURE METHODS
  • 2008. Strategies for Improving Crystallization Success Rates in STRUCTURAL PROTEOMICS
  • 1997-12. Specific versus non-specific contacts in protein crystals in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2003-05. X-ray structure of a voltage-dependent K+ channel in NATURE
  • 2003-05. Chemical physics: How to keep dry in water in NATURE
  • 2014. High-Throughput Crystallization Screening in STRUCTURAL GENOMICS AND DRUG DISCOVERY
  • 2009-01. Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data in NATURE BIOTECHNOLOGY
  • 2014. Salvage of Failed Protein Targets by Reductive Alkylation in STRUCTURAL GENOMICS AND DRUG DISCOVERY
  • 2014. Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy in STRUCTURAL GENOMICS AND DRUG DISCOVERY
  • 2005-06. Structural characterization of the molecular platform for type III secretion system assembly in NATURE
  • 2009-12. CRYSTALP2: sequence-based protein crystallization propensity prediction in BMC STRUCTURAL BIOLOGY
  • 2009-03. Molecular basis of transport and regulation in the Na+/betaine symporter BetP in NATURE
  • 1995-10. Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-12. Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-7000-1_4

    DOI

    http://dx.doi.org/10.1007/978-1-4939-7000-1_4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085748046

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28573570


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Physical Chemistry (incl. Structural)", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computational Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crystallization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crystallography, X-Ray", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Conformation, alpha-Helical", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Conformation, beta-Strand", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Engineering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Solubility", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Surface Properties", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thermodynamics", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Virginia", 
              "id": "https://www.grid.ac/institutes/grid.27755.32", 
              "name": [
                "Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Derewenda", 
            "givenName": "Zygmunt S.", 
            "id": "sg:person.01004232741.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004232741.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Bioinformatics and Systems Biology Program, Sanford Burnham Prebys Medical Discovery Institute"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Godzik", 
            "givenName": "Adam", 
            "id": "sg:person.01064406065.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064406065.43"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1472-6807-7-46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000032000", 
              "https://doi.org/10.1186/1472-6807-7-46"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2007.08.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000060983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ars.2012.4563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000215999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1261671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000321118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.04809404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001323519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.20789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001529666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.20789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001529666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.08.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002124803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2014.08.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002147823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057114548832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002167853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1087057114548832", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002167853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0507651102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002357826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0507651102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002357826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0076-6879(97)76058-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002508455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2012.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002549522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.abb.2016.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002731232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.abb.2016.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002731232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12964-014-0080-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003138201", 
              "https://doi.org/10.1186/s12964-014-0080-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12964-014-0080-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003138201", 
              "https://doi.org/10.1186/s12964-014-0080-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.22394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003325902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s1744309110053479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003406595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.0219103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003995509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1082708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004116568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s090744490201394x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004716264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004778261", 
              "https://doi.org/10.1038/nature03554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004778261", 
              "https://doi.org/10.1038/nature03554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004793772", 
              "https://doi.org/10.1038/ncomms8125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711209105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005434906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2010.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005503804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac9176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005594702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac9176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005594702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005935925", 
              "https://doi.org/10.1038/nsmb1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005935925", 
              "https://doi.org/10.1038/nsmb1164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)80069-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006249001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444901003122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006339507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-440x(00)00172-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006380426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2004.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006540616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2004.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006540616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2004.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006540616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.17.9465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006744301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2006.12.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006787822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2016.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007052464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pep.2008.06.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007771222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pep.2008.06.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007771222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cg049977w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008212584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cg049977w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008212584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1150577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008512367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth1008-853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008724662", 
              "https://doi.org/10.1038/nmeth1008-853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/prep.2001.1392", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009187145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-2126(01)00620-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009595000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889803012421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009939765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jim.2004.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010058491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010388805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.24.9980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011429879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.05.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011446438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560061021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011455013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-62703-691-7_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011632750", 
              "https://doi.org/10.1007/978-1-62703-691-7_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2009.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011720192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.83.22.8452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012640082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012912271", 
              "https://doi.org/10.1038/nrm2767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012912271", 
              "https://doi.org/10.1038/nrm2767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2008.06.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013327861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bth300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013558375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdg359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013848814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.061411798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014352233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.2951987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014353651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2008.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014961753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2008.11.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014961753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015034705", 
              "https://doi.org/10.1038/nature07599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/febs.12796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015084295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015267854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015518370", 
              "https://doi.org/10.1038/nbt.1514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.04.063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015934095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0700149104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016205510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.1288684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017196156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1314080110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017309125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0134(19990815)36:3<332::aid-prot7>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017664198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(02)00714-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017777140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(02)00714-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017777140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0005094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017801644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/423025a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017806015", 
              "https://doi.org/10.1038/423025a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/423025a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017806015", 
              "https://doi.org/10.1038/423025a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444903015415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017955453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2012.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018574809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2012.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018574809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1994.1300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019011521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1121018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019170932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.110.168799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019594067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2007.04.072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019697897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1998.2439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020143101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.04917504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020154633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.277.5334.1975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020415498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(87)90679-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020497993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0076-6879(77)47047-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020500626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444905035237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020662568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.037564.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020678591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.037564.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020678591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020784108", 
              "https://doi.org/10.1038/nature06931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0307204101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020785267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020943841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq1059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021470375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2015.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021566973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2015.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021566973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2015.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021566973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.colsurfb.2015.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021566973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444907068217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022171352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444994001216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022343738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909009500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022627003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2015.06.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022732102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2015.06.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022732102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2015.06.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022732102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2015.06.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022732102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1000694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022778876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s1744309107050993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023176182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(02)01149-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023560511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(02)01149-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023560511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(02)01149-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023560511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btr229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023770996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(92)90639-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024082698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(02)01281-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024311708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(02)01281-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024311708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2006.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024378438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444907010931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024427339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cbic.201402597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024607814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024691541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep07016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024992419", 
              "https://doi.org/10.1038/srep07016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0050106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025511231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6807-9-50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025638606", 
              "https://doi.org/10.1186/1472-6807-9-50"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.062491906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026006092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biophys.37.032807.125817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026164216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2008.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026440427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s2053230x14002386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026629599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-2126(01)00266-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027132359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2006.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027729587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c4fd00217b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028513419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2009.12.059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028793702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/gzu002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029048412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2005.10.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029669113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2004.09.076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030209790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm501578n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030231912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444902014312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030274176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444903026271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030479003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-2126(01)00590-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031063544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(01)01938-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031176643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb1095-842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031329259", 
              "https://doi.org/10.1038/nsb1095-842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(01)76042-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031676099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2006.04.076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031678560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btm477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031802456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2015.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032407811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2015.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032407811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2015.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032407811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.037812", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032869229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10969-010-9079-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033181710", 
              "https://doi.org/10.1007/s10969-010-9079-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10969-010-9079-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033181710", 
              "https://doi.org/10.1007/s10969-010-9079-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.340230413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034134178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.340230413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034134178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/133794b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034294317", 
              "https://doi.org/10.1038/133794b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/133794b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034294317", 
              "https://doi.org/10.1038/133794b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1112595109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034426369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b614955c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034482159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c0cp02296a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034651195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmc.2013.06.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034998325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.0243403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035109491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036111824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036244124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/1478-3967/1/1/p02", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036291427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2008.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036896722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2008.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036896722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jcis.2001.7671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037030998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s160057671302880x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037307034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.o115.052209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037536537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.035121.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037590470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0401786101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037657677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037826339", 
              "https://doi.org/10.1038/13783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037826339", 
              "https://doi.org/10.1038/13783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/31405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038246480", 
              "https://doi.org/10.1038/31405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/31405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038246480", 
              "https://doi.org/10.1038/31405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.2174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038463982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0050007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038559067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/174946a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038739170", 
              "https://doi.org/10.1038/174946a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444908035440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039158664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0076-6879(03)68006-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039164063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(98)01430-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039931358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2008.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040407019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-0354-2_12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040744077", 
              "https://doi.org/10.1007/978-1-4939-0354-2_12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pntd.0002775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040942053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2003.11.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042203636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2007.05.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042204379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2000.4171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042365810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s090744491000644x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042464127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s090744491000644x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042464127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2005.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042539838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c3sm52175c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042771447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2014.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043176958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043513481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043513481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560040607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043542467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2015.11.078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043542720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-440x(02)00354-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043815555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-440x(02)00354-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043815555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1150609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043965657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2007.08.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044146123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444904015422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044554226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0101123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044899652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560060822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045005538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2010.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045379019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2010.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045379019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.072914007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045480214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.4935369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045646011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb1295-1062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045906059", 
              "https://doi.org/10.1038/nsb1295-1062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s1744309112035348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046417424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444902016359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046539433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046608420", 
              "https://doi.org/10.1038/nature01580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046608420", 
              "https://doi.org/10.1038/nature01580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2006.11.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046992293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2011.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047067167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2011.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047067167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2011.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047067167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047811726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.20766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047866532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.20766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047866532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2009.09.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047979478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth1118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048077604", 
              "https://doi.org/10.1038/nmeth1118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1047-8477(03)00038-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048525002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1047-8477(03)00038-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048525002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10969-011-9106-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049148828", 
              "https://doi.org/10.1007/s10969-011-9106-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.7.4115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049251709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.endeavour.2004.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049340219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/82823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049408892", 
              "https://doi.org/10.1038/82823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-0354-2_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049820077", 
              "https://doi.org/10.1007/978-1-4939-0354-2_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-60327-058-8_22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050163823", 
              "https://doi.org/10.1007/978-1-60327-058-8_22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cg101308r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050338786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cg101308r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050338786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4939-0354-2_15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050678549", 
              "https://doi.org/10.1007/978-1-4939-0354-2_15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s1399004713032070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050936517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s1399004713032070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050936517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051414479", 
              "https://doi.org/10.1038/nature07819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb1297-973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051448176", 
              "https://doi.org/10.1038/nsb1297-973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051712113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0005-2736(02)00398-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051768164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444993014301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052294473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2004.1498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052312070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10969-010-9080-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053244546", 
              "https://doi.org/10.1007/s10969-010-9080-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10969-010-9080-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053244546", 
              "https://doi.org/10.1007/s10969-010-9080-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(98)01253-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053327498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560070715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053407199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cr020689l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054052288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cr020689l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054052288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jmedchem.5b01412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055099784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acsmedchemlett.5b00254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055136503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc00001a001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055152500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0261645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055196015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi0261645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055196015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi201287e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055204554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi201287e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055204554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi900017q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi900017q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi990381x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055217541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi990381x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055217541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cg900919w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055399262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cg900919w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055399262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja043218k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055835846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja043218k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055835846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm049388p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm049388p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm061046r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055950745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm061046r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055950745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm4000984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055953648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm501908a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055955050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm800914n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055955899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm800914n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055955899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp5011428", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056099754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.1569473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057721302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.1638377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057728719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.474547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058057676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/3.1.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059980470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.103.018101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060755633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.103.018101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060755633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.76.150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060812623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1103/physrevlett.76.150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060812623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.264.5159.670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062548081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8316857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062654660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138920307780363433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069179168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075929870", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077634655", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083052716", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017", 
        "datePublishedReg": "2017-01-01", 
        "description": "Crystallization of macromolecules has long been perceived as a stochastic process, which cannot be predicted or controlled. This is consistent with another popular notion that the interactions of molecules within the crystal, i.e., crystal contacts, are essentially random and devoid of specific physicochemical features. In contrast, functionally relevant surfaces, such as oligomerization interfaces and specific protein-protein interaction sites, are under evolutionary pressures so their amino acid composition, structure, and topology are distinct. However, current theoretical and experimental studies are significantly changing our understanding of the nature of crystallization. The increasingly popular \"sticky patch\" model, derived from soft matter physics, describes crystallization as a process driven by interactions between select, specific surface patches, with properties thermodynamically favorable for cohesive interactions. Independent support for this model comes from various sources including structural studies and bioinformatics. Proteins that are recalcitrant to crystallization can be modified for enhanced crystallizability through chemical or mutational modification of their surface to effectively engineer \"sticky patches\" which would drive crystallization. Here, we discuss the current state of knowledge of the relationship between the microscopic properties of the target macromolecule and its crystallizability, focusing on the \"sticky patch\" model. We discuss state-of-the-art in silico methods that evaluate the propensity of a given target protein to form crystals based on these relationships, with the objective to design variants with modified molecular surface properties and enhanced crystallization propensity. We illustrate this discussion with specific cases where these approaches allowed to generate crystals suitable for structural analysis.", 
        "editor": [
          {
            "familyName": "Wlodawer", 
            "givenName": "Alexander", 
            "type": "Person"
          }, 
          {
            "familyName": "Dauter", 
            "givenName": "Zbigniew", 
            "type": "Person"
          }, 
          {
            "familyName": "Jaskolski", 
            "givenName": "Mariusz", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-1-4939-7000-1_4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2521042", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": {
          "isbn": [
            "978-1-4939-6998-2", 
            "978-1-4939-7000-1"
          ], 
          "name": "Protein Crystallography", 
          "type": "Book"
        }, 
        "name": "The \u201cSticky Patch\u201d Model of Crystallization and Modification of Proteins for Enhanced Crystallizability", 
        "pagination": "77-115", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-1-4939-7000-1_4"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e18dd3ea13ec0ad56475b7e2e3a9b8c6809dc9df55910e7ee91bbbe1dd43770c"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085748046"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28573570"
            ]
          }
        ], 
        "publisher": {
          "location": "New York, NY", 
          "name": "Springer New York", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-1-4939-7000-1_4", 
          "https://app.dimensions.ai/details/publication/pub.1085748046"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-15T12:50", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000427.jsonl", 
        "type": "Chapter", 
        "url": "http://link.springer.com/10.1007/978-1-4939-7000-1_4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7000-1_4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7000-1_4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7000-1_4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-7000-1_4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    856 TRIPLES      23 PREDICATES      269 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-1-4939-7000-1_4 schema:about N096daf388c5643daaba27fadce3f23d3
    2 N0f228730c56249b89727831fded34d74
    3 N1887bca2bbcc4e6e8a74ce17f328dbf2
    4 N39cf6fe3422247f383df9b560b320fc6
    5 N40786f173a0944e7a9da21430be959d6
    6 N78e0bfdc17294425aab48ed84f191b23
    7 N8d0ead28d0394d55aad4e26f54884b9e
    8 Nb025dc7d3fbe469db0403e423bf8cc3b
    9 Nc495a32a7dad4b21a705bf77971269e1
    10 Ncf5c1531b50149e1a9bf87525268707a
    11 Nd5e0923c77ec4b269d6234021a037319
    12 Ne07e263cf7c042e3bd2995d5ec31d851
    13 Ne2ddf7574ac44a54bb0fd6dc5d51ed01
    14 Ne5428d4ec02b4d56a153769cbf286ee5
    15 anzsrc-for:03
    16 anzsrc-for:0306
    17 schema:author Nad9d896fafa9489aaae322b1fe58f8a7
    18 schema:citation sg:pub.10.1007/978-1-4939-0354-2_12
    19 sg:pub.10.1007/978-1-4939-0354-2_15
    20 sg:pub.10.1007/978-1-4939-0354-2_16
    21 sg:pub.10.1007/978-1-60327-058-8_22
    22 sg:pub.10.1007/978-1-62703-691-7_1
    23 sg:pub.10.1007/s10969-010-9079-6
    24 sg:pub.10.1007/s10969-010-9080-0
    25 sg:pub.10.1007/s10969-011-9106-2
    26 sg:pub.10.1038/133794b0
    27 sg:pub.10.1038/13783
    28 sg:pub.10.1038/174946a0
    29 sg:pub.10.1038/31405
    30 sg:pub.10.1038/423025a
    31 sg:pub.10.1038/82823
    32 sg:pub.10.1038/nature01580
    33 sg:pub.10.1038/nature03554
    34 sg:pub.10.1038/nature06931
    35 sg:pub.10.1038/nature07599
    36 sg:pub.10.1038/nature07819
    37 sg:pub.10.1038/nbt.1514
    38 sg:pub.10.1038/ncomms8125
    39 sg:pub.10.1038/nmeth1008-853
    40 sg:pub.10.1038/nmeth1118
    41 sg:pub.10.1038/nrm2767
    42 sg:pub.10.1038/nsb1095-842
    43 sg:pub.10.1038/nsb1295-1062
    44 sg:pub.10.1038/nsb1297-973
    45 sg:pub.10.1038/nsmb1164
    46 sg:pub.10.1038/srep07016
    47 sg:pub.10.1186/1472-6807-7-46
    48 sg:pub.10.1186/1472-6807-9-50
    49 sg:pub.10.1186/s12964-014-0080-8
    50 https://app.dimensions.ai/details/publication/pub.1075929870
    51 https://app.dimensions.ai/details/publication/pub.1077634655
    52 https://app.dimensions.ai/details/publication/pub.1083052716
    53 https://doi.org/10.1002/(sici)1097-0134(19990815)36:3<332::aid-prot7>3.0.co;2-h
    54 https://doi.org/10.1002/cbic.201402597
    55 https://doi.org/10.1002/pro.145
    56 https://doi.org/10.1002/pro.162
    57 https://doi.org/10.1002/pro.2174
    58 https://doi.org/10.1002/pro.420
    59 https://doi.org/10.1002/pro.5560040607
    60 https://doi.org/10.1002/pro.5560060822
    61 https://doi.org/10.1002/pro.5560061021
    62 https://doi.org/10.1002/pro.5560070715
    63 https://doi.org/10.1002/pro.690
    64 https://doi.org/10.1002/pro.727
    65 https://doi.org/10.1002/prot.20766
    66 https://doi.org/10.1002/prot.20789
    67 https://doi.org/10.1002/prot.22394
    68 https://doi.org/10.1002/prot.340230413
    69 https://doi.org/10.1006/jcis.2001.7671
    70 https://doi.org/10.1006/jmbi.1994.1300
    71 https://doi.org/10.1006/jmbi.1998.2439
    72 https://doi.org/10.1006/jmbi.2000.4171
    73 https://doi.org/10.1006/prep.2001.1392
    74 https://doi.org/10.1016/0022-2836(87)90679-6
    75 https://doi.org/10.1016/0022-2836(92)90639-2
    76 https://doi.org/10.1016/0076-6879(77)47047-2
    77 https://doi.org/10.1016/j.abb.2016.01.004
    78 https://doi.org/10.1016/j.bbrc.2009.09.036
    79 https://doi.org/10.1016/j.bmc.2013.06.014
    80 https://doi.org/10.1016/j.bmcl.2005.10.032
    81 https://doi.org/10.1016/j.bmcl.2006.04.076
    82 https://doi.org/10.1016/j.bmcl.2006.11.003
    83 https://doi.org/10.1016/j.bmcl.2006.12.051
    84 https://doi.org/10.1016/j.bmcl.2007.04.072
    85 https://doi.org/10.1016/j.bmcl.2007.08.040
    86 https://doi.org/10.1016/j.bmcl.2015.06.074
    87 https://doi.org/10.1016/j.bmcl.2015.11.078
    88 https://doi.org/10.1016/j.cell.2007.01.035
    89 https://doi.org/10.1016/j.cell.2009.04.063
    90 https://doi.org/10.1016/j.colsurfb.2015.07.023
    91 https://doi.org/10.1016/j.endeavour.2004.01.010
    92 https://doi.org/10.1016/j.febslet.2009.12.059
    93 https://doi.org/10.1016/j.jim.2004.04.008
    94 https://doi.org/10.1016/j.jmb.2003.11.053
    95 https://doi.org/10.1016/j.jmb.2004.05.051
    96 https://doi.org/10.1016/j.jmb.2004.08.037
    97 https://doi.org/10.1016/j.jmb.2004.09.076
    98 https://doi.org/10.1016/j.jmb.2007.05.022
    99 https://doi.org/10.1016/j.jmb.2007.08.027
    100 https://doi.org/10.1016/j.jmb.2008.06.014
    101 https://doi.org/10.1016/j.jmb.2015.06.004
    102 https://doi.org/10.1016/j.jmb.2016.03.002
    103 https://doi.org/10.1016/j.jsb.2006.09.006
    104 https://doi.org/10.1016/j.jsb.2008.11.008
    105 https://doi.org/10.1016/j.jsb.2010.06.008
    106 https://doi.org/10.1016/j.jsb.2010.07.011
    107 https://doi.org/10.1016/j.jsb.2012.05.009
    108 https://doi.org/10.1016/j.jsb.2014.12.007
    109 https://doi.org/10.1016/j.pep.2008.06.017
    110 https://doi.org/10.1016/j.sbi.2009.04.008
    111 https://doi.org/10.1016/j.str.2006.09.005
    112 https://doi.org/10.1016/j.str.2008.08.010
    113 https://doi.org/10.1016/j.str.2008.08.018
    114 https://doi.org/10.1016/j.str.2008.11.011
    115 https://doi.org/10.1016/j.str.2012.04.010
    116 https://doi.org/10.1016/j.str.2014.08.022
    117 https://doi.org/10.1016/j.tibtech.2005.09.006
    118 https://doi.org/10.1016/j.ymeth.2004.03.028
    119 https://doi.org/10.1016/j.ymeth.2011.02.006
    120 https://doi.org/10.1016/s0005-2736(02)00398-x
    121 https://doi.org/10.1016/s0006-3495(01)76042-0
    122 https://doi.org/10.1016/s0022-2836(02)00714-3
    123 https://doi.org/10.1016/s0022-2836(02)01149-x
    124 https://doi.org/10.1016/s0022-2836(02)01281-0
    125 https://doi.org/10.1016/s0076-6879(03)68006-7
    126 https://doi.org/10.1016/s0076-6879(97)76058-0
    127 https://doi.org/10.1016/s0168-9525(98)01430-9
    128 https://doi.org/10.1016/s0959-440x(00)00172-x
    129 https://doi.org/10.1016/s0959-440x(02)00354-8
    130 https://doi.org/10.1016/s0960-9822(00)80069-x
    131 https://doi.org/10.1016/s0968-0004(01)01938-7
    132 https://doi.org/10.1016/s0968-0004(98)01253-5
    133 https://doi.org/10.1016/s0969-2126(01)00266-0
    134 https://doi.org/10.1016/s0969-2126(01)00590-1
    135 https://doi.org/10.1016/s0969-2126(01)00620-7
    136 https://doi.org/10.1016/s1047-8477(03)00038-8
    137 https://doi.org/10.1021/acs.jmedchem.5b01412
    138 https://doi.org/10.1021/acsmedchemlett.5b00254
    139 https://doi.org/10.1021/bc00001a001
    140 https://doi.org/10.1021/bi0261645
    141 https://doi.org/10.1021/bi201287e
    142 https://doi.org/10.1021/bi900017q
    143 https://doi.org/10.1021/bi990381x
    144 https://doi.org/10.1021/cg049977w
    145 https://doi.org/10.1021/cg101308r
    146 https://doi.org/10.1021/cg900919w
    147 https://doi.org/10.1021/cr020689l
    148 https://doi.org/10.1021/ja043218k
    149 https://doi.org/10.1021/jm049388p
    150 https://doi.org/10.1021/jm061046r
    151 https://doi.org/10.1021/jm4000984
    152 https://doi.org/10.1021/jm501578n
    153 https://doi.org/10.1021/jm501908a
    154 https://doi.org/10.1021/jm800914n
    155 https://doi.org/10.1021/jp5011428
    156 https://doi.org/10.1039/b614955c
    157 https://doi.org/10.1039/c0cp02296a
    158 https://doi.org/10.1039/c3sm52175c
    159 https://doi.org/10.1039/c4fd00217b
    160 https://doi.org/10.1063/1.1288684
    161 https://doi.org/10.1063/1.1569473
    162 https://doi.org/10.1063/1.1638377
    163 https://doi.org/10.1063/1.2951987
    164 https://doi.org/10.1063/1.474547
    165 https://doi.org/10.1063/1.4935369
    166 https://doi.org/10.1073/pnas.0307204101
    167 https://doi.org/10.1073/pnas.0401786101
    168 https://doi.org/10.1073/pnas.0507651102
    169 https://doi.org/10.1073/pnas.061411798
    170 https://doi.org/10.1073/pnas.0700149104
    171 https://doi.org/10.1073/pnas.0711209105
    172 https://doi.org/10.1073/pnas.1112595109
    173 https://doi.org/10.1073/pnas.1314080110
    174 https://doi.org/10.1073/pnas.83.22.8452
    175 https://doi.org/10.1073/pnas.87.24.9980
    176 https://doi.org/10.1073/pnas.96.17.9465
    177 https://doi.org/10.1074/jbc.274.7.4115
    178 https://doi.org/10.1074/jbc.m109.037812
    179 https://doi.org/10.1074/mcp.o115.052209
    180 https://doi.org/10.1088/1478-3967/1/1/p02
    181 https://doi.org/10.1089/ars.2012.4563
    182 https://doi.org/10.1093/bioinformatics/bth300
    183 https://doi.org/10.1093/bioinformatics/btm477
    184 https://doi.org/10.1093/bioinformatics/btn055
    185 https://doi.org/10.1093/bioinformatics/btr229
    186 https://doi.org/10.1093/emboj/cdg359
    187 https://doi.org/10.1093/nar/gkn464
    188 https://doi.org/10.1093/nar/gkq1059
    189 https://doi.org/10.1093/protein/3.1.1
    190 https://doi.org/10.1093/protein/gzu002
    191 https://doi.org/10.1098/rstb.2004.1498
    192 https://doi.org/10.1103/physrevlett.103.018101
    193 https://doi.org/10.1103/physrevlett.76.150
    194 https://doi.org/10.1104/pp.110.168799
    195 https://doi.org/10.1107/s0021889803012421
    196 https://doi.org/10.1107/s0907444901003122
    197 https://doi.org/10.1107/s090744490201394x
    198 https://doi.org/10.1107/s0907444902014312
    199 https://doi.org/10.1107/s0907444902016359
    200 https://doi.org/10.1107/s0907444903015415
    201 https://doi.org/10.1107/s0907444903026271
    202 https://doi.org/10.1107/s0907444904015422
    203 https://doi.org/10.1107/s0907444905035237
    204 https://doi.org/10.1107/s0907444907010931
    205 https://doi.org/10.1107/s0907444907068217
    206 https://doi.org/10.1107/s0907444908035440
    207 https://doi.org/10.1107/s0907444909009500
    208 https://doi.org/10.1107/s090744491000644x
    209 https://doi.org/10.1107/s0907444993014301
    210 https://doi.org/10.1107/s0907444994001216
    211 https://doi.org/10.1107/s1399004713032070
    212 https://doi.org/10.1107/s160057671302880x
    213 https://doi.org/10.1107/s1744309107050993
    214 https://doi.org/10.1107/s1744309110053479
    215 https://doi.org/10.1107/s1744309112035348
    216 https://doi.org/10.1107/s2053230x14002386
    217 https://doi.org/10.1110/ps.0219103
    218 https://doi.org/10.1110/ps.0243403
    219 https://doi.org/10.1110/ps.035121.108
    220 https://doi.org/10.1110/ps.037564.108
    221 https://doi.org/10.1110/ps.04809404
    222 https://doi.org/10.1110/ps.04917504
    223 https://doi.org/10.1110/ps.062491906
    224 https://doi.org/10.1110/ps.072914007
    225 https://doi.org/10.1111/febs.12796
    226 https://doi.org/10.1126/science.1082708
    227 https://doi.org/10.1126/science.1121018
    228 https://doi.org/10.1126/science.1150577
    229 https://doi.org/10.1126/science.1150609
    230 https://doi.org/10.1126/science.1261671
    231 https://doi.org/10.1126/science.264.5159.670
    232 https://doi.org/10.1126/science.277.5334.1975
    233 https://doi.org/10.1126/science.8316857
    234 https://doi.org/10.1126/science.aac9176
    235 https://doi.org/10.1146/annurev.biophys.37.032807.125817
    236 https://doi.org/10.1146/annurev.immunol.21.120601.141036
    237 https://doi.org/10.1177/1087057114548832
    238 https://doi.org/10.1371/journal.pbio.0050007
    239 https://doi.org/10.1371/journal.pbio.0050106
    240 https://doi.org/10.1371/journal.pcbi.1000694
    241 https://doi.org/10.1371/journal.pntd.0002775
    242 https://doi.org/10.1371/journal.pone.0005094
    243 https://doi.org/10.1371/journal.pone.0101123
    244 https://doi.org/10.2174/138920307780363433
    245 schema:datePublished 2017
    246 schema:datePublishedReg 2017-01-01
    247 schema:description Crystallization of macromolecules has long been perceived as a stochastic process, which cannot be predicted or controlled. This is consistent with another popular notion that the interactions of molecules within the crystal, i.e., crystal contacts, are essentially random and devoid of specific physicochemical features. In contrast, functionally relevant surfaces, such as oligomerization interfaces and specific protein-protein interaction sites, are under evolutionary pressures so their amino acid composition, structure, and topology are distinct. However, current theoretical and experimental studies are significantly changing our understanding of the nature of crystallization. The increasingly popular "sticky patch" model, derived from soft matter physics, describes crystallization as a process driven by interactions between select, specific surface patches, with properties thermodynamically favorable for cohesive interactions. Independent support for this model comes from various sources including structural studies and bioinformatics. Proteins that are recalcitrant to crystallization can be modified for enhanced crystallizability through chemical or mutational modification of their surface to effectively engineer "sticky patches" which would drive crystallization. Here, we discuss the current state of knowledge of the relationship between the microscopic properties of the target macromolecule and its crystallizability, focusing on the "sticky patch" model. We discuss state-of-the-art in silico methods that evaluate the propensity of a given target protein to form crystals based on these relationships, with the objective to design variants with modified molecular surface properties and enhanced crystallization propensity. We illustrate this discussion with specific cases where these approaches allowed to generate crystals suitable for structural analysis.
    248 schema:editor N8d7c72fff4624433a5ab8fd4c4c693ef
    249 schema:genre chapter
    250 schema:inLanguage en
    251 schema:isAccessibleForFree true
    252 schema:isPartOf N453442a1f076418bacb6ce6dc8a9a810
    253 schema:name The “Sticky Patch” Model of Crystallization and Modification of Proteins for Enhanced Crystallizability
    254 schema:pagination 77-115
    255 schema:productId N3c811ceb09474a22b43146ba1cd98541
    256 N4330a9ce13c642d9bd41c1d4739121b8
    257 N67df4047ba3d46989fa3c1f1a1c43585
    258 N6e59d0735f6b47dbbf16de2969f386b7
    259 schema:publisher N35a58d53cb794233aaf6b588c493d9e2
    260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085748046
    261 https://doi.org/10.1007/978-1-4939-7000-1_4
    262 schema:sdDatePublished 2019-04-15T12:50
    263 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    264 schema:sdPublisher N8664061337c34928ad1e44f97d226c54
    265 schema:url http://link.springer.com/10.1007/978-1-4939-7000-1_4
    266 sgo:license sg:explorer/license/
    267 sgo:sdDataset chapters
    268 rdf:type schema:Chapter
    269 N096daf388c5643daaba27fadce3f23d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    270 schema:name Crystallography, X-Ray
    271 rdf:type schema:DefinedTerm
    272 N0f228730c56249b89727831fded34d74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    273 schema:name Mutation
    274 rdf:type schema:DefinedTerm
    275 N1887bca2bbcc4e6e8a74ce17f328dbf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    276 schema:name Proteins
    277 rdf:type schema:DefinedTerm
    278 N1e0d2edcc4404c23820dbeb1efd91bd0 schema:name Bioinformatics and Systems Biology Program, Sanford Burnham Prebys Medical Discovery Institute
    279 rdf:type schema:Organization
    280 N2373335c01b745809228e068f2f3a547 schema:familyName Wlodawer
    281 schema:givenName Alexander
    282 rdf:type schema:Person
    283 N35a58d53cb794233aaf6b588c493d9e2 schema:location New York, NY
    284 schema:name Springer New York
    285 rdf:type schema:Organisation
    286 N39cf6fe3422247f383df9b560b320fc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    287 schema:name Protein Engineering
    288 rdf:type schema:DefinedTerm
    289 N3c811ceb09474a22b43146ba1cd98541 schema:name dimensions_id
    290 schema:value pub.1085748046
    291 rdf:type schema:PropertyValue
    292 N3e89bc3769f3490889d8b126a7cf6b79 rdf:first Ne9231ba868434f6a9e733030190e01ac
    293 rdf:rest rdf:nil
    294 N40786f173a0944e7a9da21430be959d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Crystallization
    296 rdf:type schema:DefinedTerm
    297 N4330a9ce13c642d9bd41c1d4739121b8 schema:name doi
    298 schema:value 10.1007/978-1-4939-7000-1_4
    299 rdf:type schema:PropertyValue
    300 N453442a1f076418bacb6ce6dc8a9a810 schema:isbn 978-1-4939-6998-2
    301 978-1-4939-7000-1
    302 schema:name Protein Crystallography
    303 rdf:type schema:Book
    304 N67df4047ba3d46989fa3c1f1a1c43585 schema:name readcube_id
    305 schema:value e18dd3ea13ec0ad56475b7e2e3a9b8c6809dc9df55910e7ee91bbbe1dd43770c
    306 rdf:type schema:PropertyValue
    307 N6c03f976ec024f9b9ff297daaa72e9ba rdf:first sg:person.01064406065.43
    308 rdf:rest rdf:nil
    309 N6e59d0735f6b47dbbf16de2969f386b7 schema:name pubmed_id
    310 schema:value 28573570
    311 rdf:type schema:PropertyValue
    312 N71dce687daa042438e4082071f49442b rdf:first Nbd19b9d385cd4260be04d6454b920dec
    313 rdf:rest N3e89bc3769f3490889d8b126a7cf6b79
    314 N78e0bfdc17294425aab48ed84f191b23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    315 schema:name Amino Acids
    316 rdf:type schema:DefinedTerm
    317 N8664061337c34928ad1e44f97d226c54 schema:name Springer Nature - SN SciGraph project
    318 rdf:type schema:Organization
    319 N8d0ead28d0394d55aad4e26f54884b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    320 schema:name Gene Expression
    321 rdf:type schema:DefinedTerm
    322 N8d7c72fff4624433a5ab8fd4c4c693ef rdf:first N2373335c01b745809228e068f2f3a547
    323 rdf:rest N71dce687daa042438e4082071f49442b
    324 Nad9d896fafa9489aaae322b1fe58f8a7 rdf:first sg:person.01004232741.83
    325 rdf:rest N6c03f976ec024f9b9ff297daaa72e9ba
    326 Nb025dc7d3fbe469db0403e423bf8cc3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    327 schema:name Solubility
    328 rdf:type schema:DefinedTerm
    329 Nbd19b9d385cd4260be04d6454b920dec schema:familyName Dauter
    330 schema:givenName Zbigniew
    331 rdf:type schema:Person
    332 Nc495a32a7dad4b21a705bf77971269e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    333 schema:name Surface Properties
    334 rdf:type schema:DefinedTerm
    335 Ncf5c1531b50149e1a9bf87525268707a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    336 schema:name Thermodynamics
    337 rdf:type schema:DefinedTerm
    338 Nd5e0923c77ec4b269d6234021a037319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    339 schema:name Protein Conformation, alpha-Helical
    340 rdf:type schema:DefinedTerm
    341 Ne07e263cf7c042e3bd2995d5ec31d851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    342 schema:name Protein Conformation, beta-Strand
    343 rdf:type schema:DefinedTerm
    344 Ne2ddf7574ac44a54bb0fd6dc5d51ed01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    345 schema:name Models, Molecular
    346 rdf:type schema:DefinedTerm
    347 Ne5428d4ec02b4d56a153769cbf286ee5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    348 schema:name Computational Biology
    349 rdf:type schema:DefinedTerm
    350 Ne9231ba868434f6a9e733030190e01ac schema:familyName Jaskolski
    351 schema:givenName Mariusz
    352 rdf:type schema:Person
    353 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    354 schema:name Chemical Sciences
    355 rdf:type schema:DefinedTerm
    356 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
    357 schema:name Physical Chemistry (incl. Structural)
    358 rdf:type schema:DefinedTerm
    359 sg:grant.2521042 http://pending.schema.org/fundedItem sg:pub.10.1007/978-1-4939-7000-1_4
    360 rdf:type schema:MonetaryGrant
    361 sg:person.01004232741.83 schema:affiliation https://www.grid.ac/institutes/grid.27755.32
    362 schema:familyName Derewenda
    363 schema:givenName Zygmunt S.
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004232741.83
    365 rdf:type schema:Person
    366 sg:person.01064406065.43 schema:affiliation N1e0d2edcc4404c23820dbeb1efd91bd0
    367 schema:familyName Godzik
    368 schema:givenName Adam
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064406065.43
    370 rdf:type schema:Person
    371 sg:pub.10.1007/978-1-4939-0354-2_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040744077
    372 https://doi.org/10.1007/978-1-4939-0354-2_12
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1007/978-1-4939-0354-2_15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050678549
    375 https://doi.org/10.1007/978-1-4939-0354-2_15
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1007/978-1-4939-0354-2_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049820077
    378 https://doi.org/10.1007/978-1-4939-0354-2_16
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1007/978-1-60327-058-8_22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050163823
    381 https://doi.org/10.1007/978-1-60327-058-8_22
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1007/978-1-62703-691-7_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011632750
    384 https://doi.org/10.1007/978-1-62703-691-7_1
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1007/s10969-010-9079-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033181710
    387 https://doi.org/10.1007/s10969-010-9079-6
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1007/s10969-010-9080-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053244546
    390 https://doi.org/10.1007/s10969-010-9080-0
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1007/s10969-011-9106-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049148828
    393 https://doi.org/10.1007/s10969-011-9106-2
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/133794b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294317
    396 https://doi.org/10.1038/133794b0
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/13783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037826339
    399 https://doi.org/10.1038/13783
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/174946a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038739170
    402 https://doi.org/10.1038/174946a0
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/31405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038246480
    405 https://doi.org/10.1038/31405
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/423025a schema:sameAs https://app.dimensions.ai/details/publication/pub.1017806015
    408 https://doi.org/10.1038/423025a
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/82823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049408892
    411 https://doi.org/10.1038/82823
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/nature01580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046608420
    414 https://doi.org/10.1038/nature01580
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/nature03554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004778261
    417 https://doi.org/10.1038/nature03554
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/nature06931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020784108
    420 https://doi.org/10.1038/nature06931
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/nature07599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015034705
    423 https://doi.org/10.1038/nature07599
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/nature07819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051414479
    426 https://doi.org/10.1038/nature07819
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/nbt.1514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015518370
    429 https://doi.org/10.1038/nbt.1514
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/ncomms8125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004793772
    432 https://doi.org/10.1038/ncomms8125
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/nmeth1008-853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008724662
    435 https://doi.org/10.1038/nmeth1008-853
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/nmeth1118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048077604
    438 https://doi.org/10.1038/nmeth1118
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/nrm2767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012912271
    441 https://doi.org/10.1038/nrm2767
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1038/nsb1095-842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031329259
    444 https://doi.org/10.1038/nsb1095-842
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1038/nsb1295-1062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045906059
    447 https://doi.org/10.1038/nsb1295-1062
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1038/nsb1297-973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051448176
    450 https://doi.org/10.1038/nsb1297-973
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1038/nsmb1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005935925
    453 https://doi.org/10.1038/nsmb1164
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1038/srep07016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024992419
    456 https://doi.org/10.1038/srep07016
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1186/1472-6807-7-46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000032000
    459 https://doi.org/10.1186/1472-6807-7-46
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1186/1472-6807-9-50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025638606
    462 https://doi.org/10.1186/1472-6807-9-50
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1186/s12964-014-0080-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003138201
    465 https://doi.org/10.1186/s12964-014-0080-8
    466 rdf:type schema:CreativeWork
    467 https://app.dimensions.ai/details/publication/pub.1075929870 schema:CreativeWork
    468 https://app.dimensions.ai/details/publication/pub.1077634655 schema:CreativeWork
    469 https://app.dimensions.ai/details/publication/pub.1083052716 schema:CreativeWork
    470 https://doi.org/10.1002/(sici)1097-0134(19990815)36:3<332::aid-prot7>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1017664198
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1002/cbic.201402597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024607814
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1002/pro.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036111824
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1002/pro.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020943841
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1002/pro.2174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038463982
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1002/pro.420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036244124
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1002/pro.5560040607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043542467
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1002/pro.5560060822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045005538
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1002/pro.5560061021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011455013
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1002/pro.5560070715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053407199
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1002/pro.690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051712113
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1002/pro.727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047811726
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1002/prot.20766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047866532
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1002/prot.20789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001529666
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1002/prot.22394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003325902
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1002/prot.340230413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034134178
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1006/jcis.2001.7671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037030998
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1006/jmbi.1994.1300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019011521
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1006/jmbi.1998.2439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020143101
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1006/jmbi.2000.4171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042365810
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1006/prep.2001.1392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009187145
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1016/0022-2836(87)90679-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020497993
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1016/0022-2836(92)90639-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024082698
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1016/0076-6879(77)47047-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020500626
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1016/j.abb.2016.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002731232
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1016/j.bbrc.2009.09.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047979478
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1016/j.bmc.2013.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034998325
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1016/j.bmcl.2005.10.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029669113
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1016/j.bmcl.2006.04.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031678560
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1016/j.bmcl.2006.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046992293
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1016/j.bmcl.2006.12.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006787822
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1016/j.bmcl.2007.04.072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019697897
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1016/j.bmcl.2007.08.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044146123
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1016/j.bmcl.2015.06.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022732102
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1016/j.bmcl.2015.11.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043542720
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1016/j.cell.2007.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043513481
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1016/j.cell.2009.04.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015934095
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/j.colsurfb.2015.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021566973
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1016/j.endeavour.2004.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049340219
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1016/j.febslet.2009.12.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028793702
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1016/j.jim.2004.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010058491
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1016/j.jmb.2003.11.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042203636
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1016/j.jmb.2004.05.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011446438
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1016/j.jmb.2004.08.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002124803
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1016/j.jmb.2004.09.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030209790
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1016/j.jmb.2007.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042204379
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1016/j.jmb.2007.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000060983
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1016/j.jmb.2008.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013327861
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1016/j.jmb.2015.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032407811
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1016/j.jmb.2016.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007052464
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1016/j.jsb.2006.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027729587
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1016/j.jsb.2008.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036896722
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1016/j.jsb.2010.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045379019
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1016/j.jsb.2010.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005503804
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1016/j.jsb.2012.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018574809
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1016/j.jsb.2014.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043176958
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1016/j.pep.2008.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007771222
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1016/j.sbi.2009.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011720192
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1016/j.str.2006.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024378438
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1016/j.str.2008.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026440427
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1016/j.str.2008.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040407019
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1016/j.str.2008.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014961753
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1016/j.str.2012.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002549522
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1016/j.str.2014.08.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002147823
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1016/j.tibtech.2005.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042539838
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1016/j.ymeth.2004.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006540616
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1016/j.ymeth.2011.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047067167
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1016/s0005-2736(02)00398-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051768164
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1016/s0006-3495(01)76042-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031676099
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1016/s0022-2836(02)00714-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017777140
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1016/s0022-2836(02)01149-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023560511
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1016/s0022-2836(02)01281-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024311708
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1016/s0076-6879(03)68006-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039164063
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1016/s0076-6879(97)76058-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002508455
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1016/s0168-9525(98)01430-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039931358
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1016/s0959-440x(00)00172-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006380426
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1016/s0959-440x(02)00354-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043815555
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1016/s0960-9822(00)80069-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006249001
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1016/s0968-0004(01)01938-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031176643
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1016/s0968-0004(98)01253-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053327498
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1016/s0969-2126(01)00266-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027132359
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1016/s0969-2126(01)00590-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031063544
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1016/s0969-2126(01)00620-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009595000
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1016/s1047-8477(03)00038-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048525002
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1021/acs.jmedchem.5b01412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055099784
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1021/acsmedchemlett.5b00254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055136503
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1021/bc00001a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055152500
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1021/bi0261645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055196015
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1021/bi201287e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055204554
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1021/bi900017q schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209482
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1021/bi990381x schema:sameAs https://app.dimensions.ai/details/publication/pub.1055217541
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1021/cg049977w schema:sameAs https://app.dimensions.ai/details/publication/pub.1008212584
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1021/cg101308r schema:sameAs https://app.dimensions.ai/details/publication/pub.1050338786
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1021/cg900919w schema:sameAs https://app.dimensions.ai/details/publication/pub.1055399262
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1021/cr020689l schema:sameAs https://app.dimensions.ai/details/publication/pub.1054052288
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1021/ja043218k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055835846
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1021/jm049388p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055949039
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1021/jm061046r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055950745
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1021/jm4000984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953648
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1021/jm501578n schema:sameAs https://app.dimensions.ai/details/publication/pub.1030231912
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1021/jm501908a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055955050
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1021/jm800914n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055955899
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1021/jp5011428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056099754
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.1039/b614955c schema:sameAs https://app.dimensions.ai/details/publication/pub.1034482159
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.1039/c0cp02296a schema:sameAs https://app.dimensions.ai/details/publication/pub.1034651195
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.1039/c3sm52175c schema:sameAs https://app.dimensions.ai/details/publication/pub.1042771447
    681 rdf:type schema:CreativeWork
    682 https://doi.org/10.1039/c4fd00217b schema:sameAs https://app.dimensions.ai/details/publication/pub.1028513419
    683 rdf:type schema:CreativeWork
    684 https://doi.org/10.1063/1.1288684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017196156
    685 rdf:type schema:CreativeWork
    686 https://doi.org/10.1063/1.1569473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057721302
    687 rdf:type schema:CreativeWork
    688 https://doi.org/10.1063/1.1638377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057728719
    689 rdf:type schema:CreativeWork
    690 https://doi.org/10.1063/1.2951987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014353651
    691 rdf:type schema:CreativeWork
    692 https://doi.org/10.1063/1.474547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058057676
    693 rdf:type schema:CreativeWork
    694 https://doi.org/10.1063/1.4935369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045646011
    695 rdf:type schema:CreativeWork
    696 https://doi.org/10.1073/pnas.0307204101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020785267
    697 rdf:type schema:CreativeWork
    698 https://doi.org/10.1073/pnas.0401786101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037657677
    699 rdf:type schema:CreativeWork
    700 https://doi.org/10.1073/pnas.0507651102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002357826
    701 rdf:type schema:CreativeWork
    702 https://doi.org/10.1073/pnas.061411798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014352233
    703 rdf:type schema:CreativeWork
    704 https://doi.org/10.1073/pnas.0700149104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016205510
    705 rdf:type schema:CreativeWork
    706 https://doi.org/10.1073/pnas.0711209105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005434906
    707 rdf:type schema:CreativeWork
    708 https://doi.org/10.1073/pnas.1112595109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034426369
    709 rdf:type schema:CreativeWork
    710 https://doi.org/10.1073/pnas.1314080110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017309125
    711 rdf:type schema:CreativeWork
    712 https://doi.org/10.1073/pnas.83.22.8452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012640082
    713 rdf:type schema:CreativeWork
    714 https://doi.org/10.1073/pnas.87.24.9980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011429879
    715 rdf:type schema:CreativeWork
    716 https://doi.org/10.1073/pnas.96.17.9465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006744301
    717 rdf:type schema:CreativeWork
    718 https://doi.org/10.1074/jbc.274.7.4115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049251709
    719 rdf:type schema:CreativeWork
    720 https://doi.org/10.1074/jbc.m109.037812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032869229
    721 rdf:type schema:CreativeWork
    722 https://doi.org/10.1074/mcp.o115.052209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037536537
    723 rdf:type schema:CreativeWork
    724 https://doi.org/10.1088/1478-3967/1/1/p02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036291427
    725 rdf:type schema:CreativeWork
    726 https://doi.org/10.1089/ars.2012.4563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000215999
    727 rdf:type schema:CreativeWork
    728 https://doi.org/10.1093/bioinformatics/bth300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013558375
    729 rdf:type schema:CreativeWork
    730 https://doi.org/10.1093/bioinformatics/btm477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031802456
    731 rdf:type schema:CreativeWork
    732 https://doi.org/10.1093/bioinformatics/btn055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015267854
    733 rdf:type schema:CreativeWork
    734 https://doi.org/10.1093/bioinformatics/btr229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023770996
    735 rdf:type schema:CreativeWork
    736 https://doi.org/10.1093/emboj/cdg359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013848814
    737 rdf:type schema:CreativeWork
    738 https://doi.org/10.1093/nar/gkn464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024691541
    739 rdf:type schema:CreativeWork
    740 https://doi.org/10.1093/nar/gkq1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021470375
    741 rdf:type schema:CreativeWork
    742 https://doi.org/10.1093/protein/3.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059980470
    743 rdf:type schema:CreativeWork
    744 https://doi.org/10.1093/protein/gzu002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029048412
    745 rdf:type schema:CreativeWork
    746 https://doi.org/10.1098/rstb.2004.1498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052312070
    747 rdf:type schema:CreativeWork
    748 https://doi.org/10.1103/physrevlett.103.018101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060755633
    749 rdf:type schema:CreativeWork
    750 https://doi.org/10.1103/physrevlett.76.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060812623
    751 rdf:type schema:CreativeWork
    752 https://doi.org/10.1104/pp.110.168799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019594067
    753 rdf:type schema:CreativeWork
    754 https://doi.org/10.1107/s0021889803012421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009939765
    755 rdf:type schema:CreativeWork
    756 https://doi.org/10.1107/s0907444901003122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006339507
    757 rdf:type schema:CreativeWork
    758 https://doi.org/10.1107/s090744490201394x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004716264
    759 rdf:type schema:CreativeWork
    760 https://doi.org/10.1107/s0907444902014312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030274176
    761 rdf:type schema:CreativeWork
    762 https://doi.org/10.1107/s0907444902016359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046539433
    763 rdf:type schema:CreativeWork
    764 https://doi.org/10.1107/s0907444903015415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017955453
    765 rdf:type schema:CreativeWork
    766 https://doi.org/10.1107/s0907444903026271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030479003
    767 rdf:type schema:CreativeWork
    768 https://doi.org/10.1107/s0907444904015422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044554226
    769 rdf:type schema:CreativeWork
    770 https://doi.org/10.1107/s0907444905035237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020662568
    771 rdf:type schema:CreativeWork
    772 https://doi.org/10.1107/s0907444907010931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024427339
    773 rdf:type schema:CreativeWork
    774 https://doi.org/10.1107/s0907444907068217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022171352
    775 rdf:type schema:CreativeWork
    776 https://doi.org/10.1107/s0907444908035440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039158664
    777 rdf:type schema:CreativeWork
    778 https://doi.org/10.1107/s0907444909009500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022627003
    779 rdf:type schema:CreativeWork
    780 https://doi.org/10.1107/s090744491000644x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042464127
    781 rdf:type schema:CreativeWork
    782 https://doi.org/10.1107/s0907444993014301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052294473
    783 rdf:type schema:CreativeWork
    784 https://doi.org/10.1107/s0907444994001216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022343738
    785 rdf:type schema:CreativeWork
    786 https://doi.org/10.1107/s1399004713032070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050936517
    787 rdf:type schema:CreativeWork
    788 https://doi.org/10.1107/s160057671302880x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037307034
    789 rdf:type schema:CreativeWork
    790 https://doi.org/10.1107/s1744309107050993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023176182
    791 rdf:type schema:CreativeWork
    792 https://doi.org/10.1107/s1744309110053479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003406595
    793 rdf:type schema:CreativeWork
    794 https://doi.org/10.1107/s1744309112035348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046417424
    795 rdf:type schema:CreativeWork
    796 https://doi.org/10.1107/s2053230x14002386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026629599
    797 rdf:type schema:CreativeWork
    798 https://doi.org/10.1110/ps.0219103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003995509
    799 rdf:type schema:CreativeWork
    800 https://doi.org/10.1110/ps.0243403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035109491
    801 rdf:type schema:CreativeWork
    802 https://doi.org/10.1110/ps.035121.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037590470
    803 rdf:type schema:CreativeWork
    804 https://doi.org/10.1110/ps.037564.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020678591
    805 rdf:type schema:CreativeWork
    806 https://doi.org/10.1110/ps.04809404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001323519
    807 rdf:type schema:CreativeWork
    808 https://doi.org/10.1110/ps.04917504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020154633
    809 rdf:type schema:CreativeWork
    810 https://doi.org/10.1110/ps.062491906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026006092
    811 rdf:type schema:CreativeWork
    812 https://doi.org/10.1110/ps.072914007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045480214
    813 rdf:type schema:CreativeWork
    814 https://doi.org/10.1111/febs.12796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015084295
    815 rdf:type schema:CreativeWork
    816 https://doi.org/10.1126/science.1082708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004116568
    817 rdf:type schema:CreativeWork
    818 https://doi.org/10.1126/science.1121018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019170932
    819 rdf:type schema:CreativeWork
    820 https://doi.org/10.1126/science.1150577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008512367
    821 rdf:type schema:CreativeWork
    822 https://doi.org/10.1126/science.1150609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043965657
    823 rdf:type schema:CreativeWork
    824 https://doi.org/10.1126/science.1261671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000321118
    825 rdf:type schema:CreativeWork
    826 https://doi.org/10.1126/science.264.5159.670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062548081
    827 rdf:type schema:CreativeWork
    828 https://doi.org/10.1126/science.277.5334.1975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020415498
    829 rdf:type schema:CreativeWork
    830 https://doi.org/10.1126/science.8316857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654660
    831 rdf:type schema:CreativeWork
    832 https://doi.org/10.1126/science.aac9176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005594702
    833 rdf:type schema:CreativeWork
    834 https://doi.org/10.1146/annurev.biophys.37.032807.125817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026164216
    835 rdf:type schema:CreativeWork
    836 https://doi.org/10.1146/annurev.immunol.21.120601.141036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010388805
    837 rdf:type schema:CreativeWork
    838 https://doi.org/10.1177/1087057114548832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002167853
    839 rdf:type schema:CreativeWork
    840 https://doi.org/10.1371/journal.pbio.0050007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038559067
    841 rdf:type schema:CreativeWork
    842 https://doi.org/10.1371/journal.pbio.0050106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025511231
    843 rdf:type schema:CreativeWork
    844 https://doi.org/10.1371/journal.pcbi.1000694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022778876
    845 rdf:type schema:CreativeWork
    846 https://doi.org/10.1371/journal.pntd.0002775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040942053
    847 rdf:type schema:CreativeWork
    848 https://doi.org/10.1371/journal.pone.0005094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017801644
    849 rdf:type schema:CreativeWork
    850 https://doi.org/10.1371/journal.pone.0101123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044899652
    851 rdf:type schema:CreativeWork
    852 https://doi.org/10.2174/138920307780363433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069179168
    853 rdf:type schema:CreativeWork
    854 https://www.grid.ac/institutes/grid.27755.32 schema:alternateName University of Virginia
    855 schema:name Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine
    856 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...