CD95-Mediated Proton Regulation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017-01-12

AUTHORS

Auréa Cophignon , Mallorie Poët , Michael Monet , Michel Tauc , Laurent Counillon

ABSTRACT

The Na+/H+ exchanger NHE1 is at the crossroads of a large diversity of signaling pathways, whose activation modifies the cooperative response of the transporter to intracellular H+ ions. Here we show how the activation of the Na+/H+ exchanger NHE1 by the cleaved ligand of CD95 can be measured. We demonstrate two different methods designed to set intracellular pH at precise values. Then we show how these can be coupled to fast kinetics of lithium transport, which will enable to measure the NHE1 activity like for an enzyme, because they will yield rates of transport. More... »

PAGES

95-102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-6780-3_9

DOI

http://dx.doi.org/10.1007/978-1-4939-6780-3_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018309243

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28078585


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