Nanoparticle-Mediated X-Ray Radiation Enhancement for Cancer Therapy View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2017

AUTHORS

Autumn D. Paro , Ilanchezhian Shanmugam , Anne L. van de Ven

ABSTRACT

Metallic nanoparticles with a high atomic number release Auger electrons in response to external beam X-ray radiation. When these nanoparticles are selectively delivered to tumors, they have the potential to locally enhance the effects of radiation therapy. Optimizing the therapeutic efficacy of these nanoparticles, however, remains a challenging and time-consuming task. Here we describe three different assays that can be used to experimentally quantify and optimize the in vitro therapeutic efficacy of nanoparticle-mediated X-ray radiation enhancement. These include an IC50 extended dose response curve, clonogenic cell survival assay, and immunoblotting. Collectively, these assays provide information about whether a given nanoparticle provides radiosensitization, the extent of the radiosensitization, and the potential mechanism of radiosensitization. More... »

PAGES

391-401

References to SciGraph publications

  • 1999-02. Emerging roles of caspase-3 in apoptosis in CELL DEATH & DIFFERENTIATION
  • 2005-02-14. Clonogenic Cell Survival Assay in CHEMOSENSITIVITY
  • 2006-12. Clonogenic assay of cells in vitro in NATURE PROTOCOLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-6646-2_25

    DOI

    http://dx.doi.org/10.1007/978-1-4939-6646-2_25

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28150217


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