Ontology type: schema:Chapter Open Access: True
2017
AUTHORSAutumn D. Paro , Ilanchezhian Shanmugam , Anne L. van de Ven
ABSTRACTMetallic nanoparticles with a high atomic number release Auger electrons in response to external beam X-ray radiation. When these nanoparticles are selectively delivered to tumors, they have the potential to locally enhance the effects of radiation therapy. Optimizing the therapeutic efficacy of these nanoparticles, however, remains a challenging and time-consuming task. Here we describe three different assays that can be used to experimentally quantify and optimize the in vitro therapeutic efficacy of nanoparticle-mediated X-ray radiation enhancement. These include an IC50 extended dose response curve, clonogenic cell survival assay, and immunoblotting. Collectively, these assays provide information about whether a given nanoparticle provides radiosensitization, the extent of the radiosensitization, and the potential mechanism of radiosensitization. More... »
PAGES391-401
Cancer Nanotechnology
ISBN
978-1-4939-6644-8
978-1-4939-6646-2
http://scigraph.springernature.com/pub.10.1007/978-1-4939-6646-2_25
DOIhttp://dx.doi.org/10.1007/978-1-4939-6646-2_25
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1083404175
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28150217
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Other Physical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dose-Response Relationship, Radiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Inhibitory Concentration 50",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Metal Nanoparticles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiation-Sensitizing Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Stem Cell Assay",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "X-Rays",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Department of Chemical Engineering, Northeastern University",
"Nanomedicine Science & Technology Center, Northeastern University"
],
"type": "Organization"
},
"familyName": "Paro",
"givenName": "Autumn D.",
"id": "sg:person.014363005161.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014363005161.51"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Nanomedicine Science & Technology Center, Northeastern University",
"Department of Physics, Northeastern University"
],
"type": "Organization"
},
"familyName": "Shanmugam",
"givenName": "Ilanchezhian",
"id": "sg:person.01130773417.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130773417.00"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Nanomedicine Science & Technology Center, Northeastern University",
"Department of Physics, Northeastern University"
],
"type": "Organization"
},
"familyName": "van de Ven",
"givenName": "Anne L.",
"id": "sg:person.01173076606.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173076606.46"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1155/2010/150960",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003700040"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clon.2007.03.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005248927"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbcan.2008.12.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007170565"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkl291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013287707"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.31.2520",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015927671"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.cdd.4400476",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019573155",
"https://doi.org/10.1038/sj.cdd.4400476"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.cdd.4400476",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019573155",
"https://doi.org/10.1038/sj.cdd.4400476"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-13-1391",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023074716"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.drudis.2007.07.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026285061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molmed.2006.07.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032059219"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/caac.21332",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032745321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.med.57.121304.131431",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038178099"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.med.57.121304.131431",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038178099"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1039/c4nr03693j",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038854930"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2006.339",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038965314",
"https://doi.org/10.1038/nprot.2006.339"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2006.339",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038965314",
"https://doi.org/10.1038/nprot.2006.339"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/1-59259-869-2:021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038990876",
"https://doi.org/10.1385/1-59259-869-2:021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/0957-4484/20/37/375101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042877221"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/0957-4484/20/37/375101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042877221"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-151-8-200910200-00145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073711107"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079034127",
"type": "CreativeWork"
}
],
"datePublished": "2017",
"datePublishedReg": "2017-01-01",
"description": "Metallic nanoparticles with a high atomic number release Auger electrons in response to external beam X-ray radiation. When these nanoparticles are selectively delivered to tumors, they have the potential to locally enhance the effects of radiation therapy. Optimizing\u00a0the therapeutic efficacy of these nanoparticles, however, remains a challenging and time-consuming task. Here we describe three different assays that can be used to experimentally quantify and optimize the in vitro therapeutic efficacy of nanoparticle-mediated X-ray radiation enhancement. These include an IC50 extended dose response curve, clonogenic cell survival assay, and immunoblotting. Collectively, these assays provide information about whether a given nanoparticle provides radiosensitization, the extent of the radiosensitization, and the potential mechanism of radiosensitization.",
"editor": [
{
"familyName": "Zeineldin",
"givenName": "Reema",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-1-4939-6646-2_25",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.3806512",
"type": "MonetaryGrant"
}
],
"isPartOf": {
"isbn": [
"978-1-4939-6644-8",
"978-1-4939-6646-2"
],
"name": "Cancer Nanotechnology",
"type": "Book"
},
"name": "Nanoparticle-Mediated X-Ray Radiation Enhancement for Cancer Therapy",
"pagination": "391-401",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-1-4939-6646-2_25"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2f578a14dae685e547053c9ae0a55d9384520c5b190e1b18d9361613e12a7878"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1083404175"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28150217"
]
}
],
"publisher": {
"location": "New York, NY",
"name": "Springer New York",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-1-4939-6646-2_25",
"https://app.dimensions.ai/details/publication/pub.1083404175"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-15T10:48",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000375.jsonl",
"type": "Chapter",
"url": "http://link.springer.com/10.1007/978-1-4939-6646-2_25"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6646-2_25'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6646-2_25'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6646-2_25'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6646-2_25'
This table displays all metadata directly associated to this object as RDF triples.
188 TRIPLES
23 PREDICATES
56 URIs
32 LITERALS
20 BLANK NODES