The Classification of Protein Domains View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Natalie Dawson , Ian Sillitoe , Russell L. Marsden , Christine A. Orengo

ABSTRACT

The significant expansion in protein sequence and structure data that we are now witnessing brings with it a pressing need to bring order to the protein world. Such order enables us to gain insights into the evolution of proteins, their function and the extent to which the functional repertoire can vary across the three kingdoms of life. This has lead to the creation of a wide range of protein family classifications that aim to group proteins based upon their evolutionary relationships.In this chapter we discuss the approaches and methods that are frequently used in the classification of proteins, with a specific emphasis on the classification of protein domains. The construction of both domain sequence and domain structure databases is considered and we show how the use of domain family annotations to assign structural and functional information is enhancing our understanding of genomes. More... »

PAGES

137-164

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-6622-6_7

DOI

http://dx.doi.org/10.1007/978-1-4939-6622-6_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019960184

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27896721


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