Evaluating the Effect of HDAC8 Inhibition in Malignant Peripheral Nerve Sheath Tumors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Gonzalo Lopez , Raphael E. Pollock

ABSTRACT

Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive disease with a dismal prognosis. The disease can occur sporadically or in patients with inherited neurofibromatosis (NF-1). MPNST is typically resistant to therapeutic intervention. Hence, the need for improved therapies is warranted. Several broad spectrum histone deacetylase (HDAC) inhibitors have a high affinity for class I HDAC isoforms. Inhibition of multiple HDAC isoforms often results in undesirable side effects, while inhibiting a single isoform could possibly improve the therapeutic window and limit toxicity. Recently, HDAC8 inhibitors have been developed and in initial preclinical studies, they demonstrate anticancer efficacy. Little is known about the role of HDAC8 in MPNST. We recently revealed an anticancer effect of HDAC8 inhibition in human and murine MPNST models. The goal of our previous study was to determine the potential therapeutic efficacy of HDAC8 inhibition in MPNST. In this chapter, we briefly describe the methods for determining the role of pharmacological HDAC inhibition in MPNST. More... »

PAGES

365-374

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-6527-4_27

DOI

http://dx.doi.org/10.1007/978-1-4939-6527-4_27

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021643483

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27761835


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxamic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Sheath Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Ohio State University", 
          "id": "https://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Surgical Oncology, James Comprehensive Cancer Center, The Ohio State University"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez", 
        "givenName": "Gonzalo", 
        "id": "sg:person.01103251105.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103251105.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Ohio State University", 
          "id": "https://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Surgical Oncology, James Comprehensive Cancer Center, The Ohio State University"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pollock", 
        "givenName": "Raphael E.", 
        "id": "sg:person.07756432137.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07756432137.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000697620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2004.10.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009065865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-2714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010222592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.21274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013029959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.04-2303fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013083993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2007.02.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014590233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2007.02.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014590233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sbi.2011.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014625835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.57.897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014787826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.57.897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014787826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3500199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015032461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3500199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015032461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111871200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015819310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-9-49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017740822", 
          "https://doi.org/10.1186/1476-4598-9-49"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2009/794901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018664877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020179459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2014.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020371979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021082728", 
          "https://doi.org/10.1038/onc.2010.204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021082728", 
          "https://doi.org/10.1038/onc.2010.204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01971-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022553857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023132286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023132286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7310149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023212695", 
          "https://doi.org/10.1038/sj.cr.7310149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7310149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023212695", 
          "https://doi.org/10.1038/sj.cr.7310149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.2.765-773.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028524538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-4004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029180598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000188029.63706.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029601932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pas.0000188029.63706.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029601932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00150-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030142465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2008.9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032266708", 
          "https://doi.org/10.1038/leu.2008.9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgl008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035858724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728220903241658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037766295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m908988199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040103939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-0092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041923633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046109045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.371120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050641229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052999638", 
          "https://doi.org/10.1038/sj.onc.1207289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052999638", 
          "https://doi.org/10.1038/sj.onc.1207289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0404603101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053275756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.286.5447.2176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062567623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2009-0441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2011.1236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071531349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.7.4.14680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072291015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076607181", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017", 
    "datePublishedReg": "2017-01-01", 
    "description": "Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive disease with a dismal prognosis. The disease can occur sporadically or in patients with inherited neurofibromatosis (NF-1). MPNST is typically resistant to therapeutic intervention. Hence, the need for improved therapies is warranted. Several broad spectrum histone deacetylase (HDAC) inhibitors have a high affinity for class I HDAC isoforms. Inhibition of multiple HDAC isoforms often results in undesirable side effects, while inhibiting a single isoform could possibly improve the therapeutic window and limit toxicity. Recently, HDAC8 inhibitors have been developed and in initial preclinical studies, they demonstrate anticancer efficacy. Little is known about the role of HDAC8 in MPNST. We recently revealed an anticancer effect of HDAC8 inhibition in human and murine MPNST models. The goal of our previous study was to determine the potential therapeutic efficacy of HDAC8 inhibition in MPNST. In this chapter, we briefly describe the methods for determining the role of pharmacological HDAC inhibition in MPNST.", 
    "editor": [
      {
        "familyName": "Kr\u00e4mer", 
        "givenName": "Oliver H.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4939-6527-4_27", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2699159", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": {
      "isbn": [
        "978-1-4939-6525-0", 
        "978-1-4939-6527-4"
      ], 
      "name": "HDAC/HAT Function Assessment and Inhibitor Development", 
      "type": "Book"
    }, 
    "name": "Evaluating the Effect of HDAC8 Inhibition in Malignant Peripheral Nerve Sheath Tumors", 
    "pagination": "365-374", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4939-6527-4_27"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "671ed22864b8603e5aa89170d59f14fa8c63a645fc3de8cf5c9366aec16744b0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021643483"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27761835"
        ]
      }
    ], 
    "publisher": {
      "location": "New York, NY", 
      "name": "Springer New York", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4939-6527-4_27", 
      "https://app.dimensions.ai/details/publication/pub.1021643483"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T00:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000337.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-4939-6527-4_27"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6527-4_27'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6527-4_27'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6527-4_27'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6527-4_27'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      23 PREDICATES      82 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4939-6527-4_27 schema:about N02dd9945d77b4fb4af96c005846a46aa
2 N202ff616842142cdbb54057546f0f1a6
3 N25000cbab8a94c78b5d3154b58a9158f
4 N2ac5cc0715e2409eb97c1091311d5239
5 N419fc9e6e46a44c8910e4e9346148b90
6 N43dae4d51b3842bb953815dafe69e842
7 N4decd80ec2d84409b671122e30dc34db
8 N5c19664f19da425abf43330aa6587e35
9 N5f015a35b71a40f8aada3ce29d64728b
10 N9107c2971a3f4690ad66c2e063fd718e
11 N952e0ba14945484c905cc44d19e64683
12 N9f377f0b59e74fd1abe4ae87e622b2d3
13 Nb2646b16dba44cff9b5f999d23d4db40
14 Nb7fea360e6194582852f7a468f13b7e2
15 Nbeb3b35445944b29a23b03b52ab4dde7
16 Nca647bb356724760b4a5f7c945836517
17 Nf3fb118c6557440f82ff0aa386832f62
18 Nff92132299d3475a8f5232768b5fb576
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Nad81675700f4486daddb395176fb3d19
22 schema:citation sg:pub.10.1038/leu.2008.9
23 sg:pub.10.1038/onc.2010.204
24 sg:pub.10.1038/sj.cr.7310149
25 sg:pub.10.1038/sj.onc.1207289
26 sg:pub.10.1186/1476-4598-9-49
27 https://app.dimensions.ai/details/publication/pub.1076607181
28 https://doi.org/10.1002/jor.21274
29 https://doi.org/10.1016/j.bmcl.2007.02.064
30 https://doi.org/10.1016/j.canlet.2004.10.030
31 https://doi.org/10.1016/j.ijrobp.2010.03.010
32 https://doi.org/10.1016/j.sbi.2011.08.004
33 https://doi.org/10.1016/j.tips.2014.08.001
34 https://doi.org/10.1016/s0006-291x(03)00150-5
35 https://doi.org/10.1042/bj20021321
36 https://doi.org/10.1042/bj3500199
37 https://doi.org/10.1073/pnas.0404603101
38 https://doi.org/10.1074/jbc.m111871200
39 https://doi.org/10.1074/jbc.m112.371120
40 https://doi.org/10.1074/jbc.m908988199
41 https://doi.org/10.1093/carcin/bgl008
42 https://doi.org/10.1096/fj.04-2303fje
43 https://doi.org/10.1097/01.pas.0000188029.63706.31
44 https://doi.org/10.1126/science.286.5447.2176
45 https://doi.org/10.1128/mcb.01971-05
46 https://doi.org/10.1128/mcb.24.2.765-773.2004
47 https://doi.org/10.1155/2009/794901
48 https://doi.org/10.1158/0008-5472.can-08-0092
49 https://doi.org/10.1158/0008-5472.can-08-4004
50 https://doi.org/10.1158/0008-5472.can-10-2799
51 https://doi.org/10.1158/1078-0432.ccr-08-0684
52 https://doi.org/10.1158/1078-0432.ccr-08-2714
53 https://doi.org/10.1210/me.2009-0441
54 https://doi.org/10.1248/cpb.57.897
55 https://doi.org/10.1517/14728220903241658
56 https://doi.org/10.3892/or.2011.1236
57 https://doi.org/10.4161/auto.7.4.14680
58 schema:datePublished 2017
59 schema:datePublishedReg 2017-01-01
60 schema:description Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive disease with a dismal prognosis. The disease can occur sporadically or in patients with inherited neurofibromatosis (NF-1). MPNST is typically resistant to therapeutic intervention. Hence, the need for improved therapies is warranted. Several broad spectrum histone deacetylase (HDAC) inhibitors have a high affinity for class I HDAC isoforms. Inhibition of multiple HDAC isoforms often results in undesirable side effects, while inhibiting a single isoform could possibly improve the therapeutic window and limit toxicity. Recently, HDAC8 inhibitors have been developed and in initial preclinical studies, they demonstrate anticancer efficacy. Little is known about the role of HDAC8 in MPNST. We recently revealed an anticancer effect of HDAC8 inhibition in human and murine MPNST models. The goal of our previous study was to determine the potential therapeutic efficacy of HDAC8 inhibition in MPNST. In this chapter, we briefly describe the methods for determining the role of pharmacological HDAC inhibition in MPNST.
61 schema:editor N00f0022bb8af4af7becc650b4aa3af74
62 schema:genre chapter
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N4d5a495894304e048e18abacae2f5aea
66 schema:name Evaluating the Effect of HDAC8 Inhibition in Malignant Peripheral Nerve Sheath Tumors
67 schema:pagination 365-374
68 schema:productId N622da7893fc94966b343deca885c1388
69 N7441c72773ad42658d34ddb2cb5a0d06
70 Na7cbec25c89e4d37bf55ff6a1b3c8e7a
71 Ne3fc3fdfadc947e1ac1f8ff8d80a9c40
72 schema:publisher Nf249c94c8c6145a987ccd8837e1fe87a
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021643483
74 https://doi.org/10.1007/978-1-4939-6527-4_27
75 schema:sdDatePublished 2019-04-16T00:59
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N7c0ccc6731ae48a2840e523aaad71ad3
78 schema:url http://link.springer.com/10.1007/978-1-4939-6527-4_27
79 sgo:license sg:explorer/license/
80 sgo:sdDataset chapters
81 rdf:type schema:Chapter
82 N00f0022bb8af4af7becc650b4aa3af74 rdf:first N476640902d0d49b784acad686d5a8b0c
83 rdf:rest rdf:nil
84 N02dd9945d77b4fb4af96c005846a46aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Mice
86 rdf:type schema:DefinedTerm
87 N202ff616842142cdbb54057546f0f1a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Apoptosis
89 rdf:type schema:DefinedTerm
90 N25000cbab8a94c78b5d3154b58a9158f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Repressor Proteins
92 rdf:type schema:DefinedTerm
93 N2ac5cc0715e2409eb97c1091311d5239 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Histone Deacetylase Inhibitors
95 rdf:type schema:DefinedTerm
96 N419fc9e6e46a44c8910e4e9346148b90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Hydroxamic Acids
98 rdf:type schema:DefinedTerm
99 N43dae4d51b3842bb953815dafe69e842 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Female
101 rdf:type schema:DefinedTerm
102 N476640902d0d49b784acad686d5a8b0c schema:familyName Krämer
103 schema:givenName Oliver H.
104 rdf:type schema:Person
105 N4d5a495894304e048e18abacae2f5aea schema:isbn 978-1-4939-6525-0
106 978-1-4939-6527-4
107 schema:name HDAC/HAT Function Assessment and Inhibitor Development
108 rdf:type schema:Book
109 N4decd80ec2d84409b671122e30dc34db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Animals
111 rdf:type schema:DefinedTerm
112 N5c19664f19da425abf43330aa6587e35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Gene Expression Regulation, Neoplastic
114 rdf:type schema:DefinedTerm
115 N5f015a35b71a40f8aada3ce29d64728b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Antineoplastic Agents
117 rdf:type schema:DefinedTerm
118 N622da7893fc94966b343deca885c1388 schema:name dimensions_id
119 schema:value pub.1021643483
120 rdf:type schema:PropertyValue
121 N7441c72773ad42658d34ddb2cb5a0d06 schema:name pubmed_id
122 schema:value 27761835
123 rdf:type schema:PropertyValue
124 N7c0ccc6731ae48a2840e523aaad71ad3 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N9107c2971a3f4690ad66c2e063fd718e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Tumor Burden
128 rdf:type schema:DefinedTerm
129 N952e0ba14945484c905cc44d19e64683 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Cycle
131 rdf:type schema:DefinedTerm
132 N9f377f0b59e74fd1abe4ae87e622b2d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 Na7cbec25c89e4d37bf55ff6a1b3c8e7a schema:name readcube_id
136 schema:value 671ed22864b8603e5aa89170d59f14fa8c63a645fc3de8cf5c9366aec16744b0
137 rdf:type schema:PropertyValue
138 Nad81675700f4486daddb395176fb3d19 rdf:first sg:person.01103251105.29
139 rdf:rest Nadad056d458c4551953d627c38a03bbd
140 Nadad056d458c4551953d627c38a03bbd rdf:first sg:person.07756432137.83
141 rdf:rest rdf:nil
142 Nb2646b16dba44cff9b5f999d23d4db40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Cell Line, Tumor
144 rdf:type schema:DefinedTerm
145 Nb7fea360e6194582852f7a468f13b7e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Nerve Sheath Neoplasms
147 rdf:type schema:DefinedTerm
148 Nbeb3b35445944b29a23b03b52ab4dde7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Mice, SCID
150 rdf:type schema:DefinedTerm
151 Nca647bb356724760b4a5f7c945836517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Histone Deacetylases
153 rdf:type schema:DefinedTerm
154 Ne3fc3fdfadc947e1ac1f8ff8d80a9c40 schema:name doi
155 schema:value 10.1007/978-1-4939-6527-4_27
156 rdf:type schema:PropertyValue
157 Nf249c94c8c6145a987ccd8837e1fe87a schema:location New York, NY
158 schema:name Springer New York
159 rdf:type schema:Organisation
160 Nf3fb118c6557440f82ff0aa386832f62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Xenograft Model Antitumor Assays
162 rdf:type schema:DefinedTerm
163 Nff92132299d3475a8f5232768b5fb576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Indoles
165 rdf:type schema:DefinedTerm
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
170 schema:name Oncology and Carcinogenesis
171 rdf:type schema:DefinedTerm
172 sg:grant.2699159 http://pending.schema.org/fundedItem sg:pub.10.1007/978-1-4939-6527-4_27
173 rdf:type schema:MonetaryGrant
174 sg:person.01103251105.29 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
175 schema:familyName Lopez
176 schema:givenName Gonzalo
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103251105.29
178 rdf:type schema:Person
179 sg:person.07756432137.83 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
180 schema:familyName Pollock
181 schema:givenName Raphael E.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07756432137.83
183 rdf:type schema:Person
184 sg:pub.10.1038/leu.2008.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032266708
185 https://doi.org/10.1038/leu.2008.9
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/onc.2010.204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021082728
188 https://doi.org/10.1038/onc.2010.204
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/sj.cr.7310149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023212695
191 https://doi.org/10.1038/sj.cr.7310149
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/sj.onc.1207289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052999638
194 https://doi.org/10.1038/sj.onc.1207289
195 rdf:type schema:CreativeWork
196 sg:pub.10.1186/1476-4598-9-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017740822
197 https://doi.org/10.1186/1476-4598-9-49
198 rdf:type schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1076607181 schema:CreativeWork
200 https://doi.org/10.1002/jor.21274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013029959
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.bmcl.2007.02.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014590233
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.canlet.2004.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009065865
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.ijrobp.2010.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020179459
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.sbi.2011.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014625835
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.tips.2014.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020371979
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0006-291x(03)00150-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030142465
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1042/bj20021321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023132286
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1042/bj3500199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015032461
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1073/pnas.0404603101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053275756
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1074/jbc.m111871200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015819310
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1074/jbc.m112.371120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050641229
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1074/jbc.m908988199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040103939
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1093/carcin/bgl008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035858724
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1096/fj.04-2303fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1013083993
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1097/01.pas.0000188029.63706.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029601932
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1126/science.286.5447.2176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062567623
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1128/mcb.01971-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022553857
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1128/mcb.24.2.765-773.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028524538
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1155/2009/794901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018664877
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1158/0008-5472.can-08-0092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041923633
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1158/0008-5472.can-08-4004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029180598
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1158/0008-5472.can-10-2799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046109045
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1158/1078-0432.ccr-08-0684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000697620
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1158/1078-0432.ccr-08-2714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010222592
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1210/me.2009-0441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328446
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1248/cpb.57.897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014787826
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1517/14728220903241658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037766295
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3892/or.2011.1236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071531349
257 rdf:type schema:CreativeWork
258 https://doi.org/10.4161/auto.7.4.14680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072291015
259 rdf:type schema:CreativeWork
260 https://www.grid.ac/institutes/grid.261331.4 schema:alternateName The Ohio State University
261 schema:name Division of Surgical Oncology, James Comprehensive Cancer Center, The Ohio State University
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...