Use of Thymidine Kinase Recombinant Adenovirus and Ganciclovir Mediated Mouse Liver Preconditioning for Hepatocyte Xenotransplantation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Daniel Moreno , Leire Neri , Eva Vicente , Africa Vales , Rafael Aldabe

ABSTRACT

Hepatocyte transplantation is the best approach to maintain and propagate differentiated hepatocytes from different species. Host liver has to be adapted for transplanted hepatocytes productive engraftment and proliferation being required a chronic liver injury to eliminate host hepatocytes and provide a proliferative advantage to the transplanted hepatocytes. Most valuable mouse models for xenograft hepatocyte transplantation are based on genetically modified animals to cause a chronic liver damage and to limit host hepatocyte regeneration potential. We present a methodology that generates a chronic liver damage and can be applied to any host mouse strain and animal species based on the inoculation of a recombinant adenovirus to express herpes simplex thymidine kinase in host hepatocytes sensitizing them to ganciclovir treatment. This causes a prolonged liver damage that allows hepatocyte transplantation and generation of regenerative nodules in recipient mouse liver integrated by transplanted cells and host sinusoidal. Obtained chimeric animals maintain functional chimeric nodules for several weeks, ready to be used in any study. More... »

PAGES

179-192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-6506-9_12

DOI

http://dx.doi.org/10.1007/978-1-4939-6506-9_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013099581

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27830553


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