Ontology type: schema:Chapter
2016-10-08
AUTHORSJalil Hakimi , Sepideh Aboutorabian , Frederick To , Salvador F. Ausar , Nausheen Rahman , Roger H. Brookes
ABSTRACTMonitoring the immunological functionality of vaccine formulations is critical for vaccine development. While the traditional approach using established animal models has been relatively effective, the use of animals is costly and cumbersome, and animal models are not always reflective of a human response. The development of a human-based approach would be a major step forward in understanding how vaccine formulations might behave in humans. Here, we describe a platform methodology using fresh human whole blood (hWB) to monitor adjuvant-modulated, antigen-specific responses to vaccine formulations, which is amenable to analysis by standard immunoassays as well as a variety of other analytical techniques. More... »
PAGES295-304
Vaccine Adjuvants
ISBN
978-1-4939-6443-7
978-1-4939-6445-1
http://scigraph.springernature.com/pub.10.1007/978-1-4939-6445-1_22
DOIhttp://dx.doi.org/10.1007/978-1-4939-6445-1_22
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1042444377
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27718203
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