Screening Vaccine Formulations in Fresh Human Whole Blood View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016-10-08

AUTHORS

Jalil Hakimi , Sepideh Aboutorabian , Frederick To , Salvador F. Ausar , Nausheen Rahman , Roger H. Brookes

ABSTRACT

Monitoring the immunological functionality of vaccine formulations is critical for vaccine development. While the traditional approach using established animal models has been relatively effective, the use of animals is costly and cumbersome, and animal models are not always reflective of a human response. The development of a human-based approach would be a major step forward in understanding how vaccine formulations might behave in humans. Here, we describe a platform methodology using fresh human whole blood (hWB) to monitor adjuvant-modulated, antigen-specific responses to vaccine formulations, which is amenable to analysis by standard immunoassays as well as a variety of other analytical techniques. More... »

PAGES

295-304

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-6445-1_22

DOI

http://dx.doi.org/10.1007/978-1-4939-6445-1_22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042444377

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27718203


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