Screening Vaccine Formulations in Fresh Human Whole Blood View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016-10-08

AUTHORS

Jalil Hakimi , Sepideh Aboutorabian , Frederick To , Salvador F. Ausar , Nausheen Rahman , Roger H. Brookes

ABSTRACT

Monitoring the immunological functionality of vaccine formulations is critical for vaccine development. While the traditional approach using established animal models has been relatively effective, the use of animals is costly and cumbersome, and animal models are not always reflective of a human response. The development of a human-based approach would be a major step forward in understanding how vaccine formulations might behave in humans. Here, we describe a platform methodology using fresh human whole blood (hWB) to monitor adjuvant-modulated, antigen-specific responses to vaccine formulations, which is amenable to analysis by standard immunoassays as well as a variety of other analytical techniques. More... »

PAGES

295-304

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-6445-1_22

DOI

http://dx.doi.org/10.1007/978-1-4939-6445-1_22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042444377

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27718203


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0399", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Compounding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Evaluation, Preclinical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hakimi", 
        "givenName": "Jalil", 
        "id": "sg:person.01372575534.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372575534.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aboutorabian", 
        "givenName": "Sepideh", 
        "id": "sg:person.0643657214.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643657214.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "To", 
        "givenName": "Frederick", 
        "id": "sg:person.011224426621.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011224426621.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ausar", 
        "givenName": "Salvador F.", 
        "id": "sg:person.0723171027.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723171027.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rahman", 
        "givenName": "Nausheen", 
        "id": "sg:person.01354732604.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354732604.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brookes", 
        "givenName": "Roger H.", 
        "id": "sg:person.01322544210.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322544210.31"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2016-10-08", 
    "datePublishedReg": "2016-10-08", 
    "description": "Monitoring the immunological functionality of vaccine formulations is critical for vaccine development. While the traditional approach using established animal models has been relatively effective, the use of animals is costly and cumbersome, and animal models are not always reflective of a human response. The development of a human-based approach would be a major step forward in understanding how vaccine formulations might behave in humans. Here, we describe a platform methodology using fresh human whole blood (hWB) to monitor adjuvant-modulated, antigen-specific responses to vaccine formulations, which is amenable to analysis by standard immunoassays as well as a variety of other analytical techniques.", 
    "editor": [
      {
        "familyName": "Fox", 
        "givenName": "Christopher B.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4939-6445-1_22", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4939-6443-7", 
        "978-1-4939-6445-1"
      ], 
      "name": "Vaccine Adjuvants", 
      "type": "Book"
    }, 
    "keywords": [
      "vaccine formulations", 
      "fresh human whole blood", 
      "human whole blood", 
      "animal models", 
      "antigen-specific responses", 
      "whole blood", 
      "vaccine development", 
      "standard immunoassays", 
      "blood", 
      "response", 
      "use of animals", 
      "human response", 
      "animals", 
      "immunoassay", 
      "human-based approach", 
      "humans", 
      "development", 
      "use", 
      "platform methodology", 
      "major step", 
      "analysis", 
      "variety", 
      "model", 
      "approach", 
      "formulation", 
      "technique", 
      "traditional approaches", 
      "step", 
      "functionality", 
      "methodology", 
      "analytical techniques", 
      "immunological functionality"
    ], 
    "name": "Screening Vaccine Formulations in Fresh Human Whole Blood", 
    "pagination": "295-304", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042444377"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4939-6445-1_22"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27718203"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4939-6445-1_22", 
      "https://app.dimensions.ai/details/publication/pub.1042444377"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_305.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-1-4939-6445-1_22"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6445-1_22'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6445-1_22'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6445-1_22'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-6445-1_22'


 

This table displays all metadata directly associated to this object as RDF triples.

159 TRIPLES      23 PREDICATES      65 URIs      56 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4939-6445-1_22 schema:about N6063d68a43d448bfbf455f2653cf7cf1
2 N680746501fa64820a88c75abb98a63ea
3 N8766349b5f9247d4ad904f6cd5da10de
4 Nbf8fd9aab1fe42dd81a2cb604acb3ee8
5 Nffacd43b4f734883bcfb792cb232ba8d
6 anzsrc-for:03
7 anzsrc-for:0399
8 anzsrc-for:06
9 anzsrc-for:0601
10 schema:author N811a08941bdb44c28c56ff381a6c5979
11 schema:datePublished 2016-10-08
12 schema:datePublishedReg 2016-10-08
13 schema:description Monitoring the immunological functionality of vaccine formulations is critical for vaccine development. While the traditional approach using established animal models has been relatively effective, the use of animals is costly and cumbersome, and animal models are not always reflective of a human response. The development of a human-based approach would be a major step forward in understanding how vaccine formulations might behave in humans. Here, we describe a platform methodology using fresh human whole blood (hWB) to monitor adjuvant-modulated, antigen-specific responses to vaccine formulations, which is amenable to analysis by standard immunoassays as well as a variety of other analytical techniques.
14 schema:editor N9ec5dec4db544ebeaa17c48120547efc
15 schema:genre chapter
16 schema:inLanguage en
17 schema:isAccessibleForFree false
18 schema:isPartOf Nc461ff92885a4fb18be3d20682983756
19 schema:keywords analysis
20 analytical techniques
21 animal models
22 animals
23 antigen-specific responses
24 approach
25 blood
26 development
27 formulation
28 fresh human whole blood
29 functionality
30 human response
31 human whole blood
32 human-based approach
33 humans
34 immunoassay
35 immunological functionality
36 major step
37 methodology
38 model
39 platform methodology
40 response
41 standard immunoassays
42 step
43 technique
44 traditional approaches
45 use
46 use of animals
47 vaccine development
48 vaccine formulations
49 variety
50 whole blood
51 schema:name Screening Vaccine Formulations in Fresh Human Whole Blood
52 schema:pagination 295-304
53 schema:productId N7220c38156ee4843a6f802bf2ae4c098
54 N98afceca1ac146a8992015c0a579a333
55 Nbcbc88d7f82146e19a57d87e9b35f75c
56 schema:publisher N88f6158a7fc64d2686ea966654bec91e
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042444377
58 https://doi.org/10.1007/978-1-4939-6445-1_22
59 schema:sdDatePublished 2022-01-01T19:18
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N0c49b32d58d642a199067e6b9810fe60
62 schema:url https://doi.org/10.1007/978-1-4939-6445-1_22
63 sgo:license sg:explorer/license/
64 sgo:sdDataset chapters
65 rdf:type schema:Chapter
66 N0c49b32d58d642a199067e6b9810fe60 schema:name Springer Nature - SN SciGraph project
67 rdf:type schema:Organization
68 N219809cfd9584f3ea176508ac09d1d07 rdf:first sg:person.01354732604.20
69 rdf:rest N85a73e54137642889d25629467f9fcb7
70 N2e5bbe896bd44150ac9858528102c82b rdf:first sg:person.0643657214.95
71 rdf:rest N34848fc7be81423b9c077d0bc2bc75a8
72 N34848fc7be81423b9c077d0bc2bc75a8 rdf:first sg:person.011224426621.24
73 rdf:rest N900a1daa55934d7db3826ec40105b4b0
74 N6063d68a43d448bfbf455f2653cf7cf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Blood
76 rdf:type schema:DefinedTerm
77 N680746501fa64820a88c75abb98a63ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Drug Evaluation, Preclinical
79 rdf:type schema:DefinedTerm
80 N7220c38156ee4843a6f802bf2ae4c098 schema:name dimensions_id
81 schema:value pub.1042444377
82 rdf:type schema:PropertyValue
83 N811a08941bdb44c28c56ff381a6c5979 rdf:first sg:person.01372575534.26
84 rdf:rest N2e5bbe896bd44150ac9858528102c82b
85 N85a73e54137642889d25629467f9fcb7 rdf:first sg:person.01322544210.31
86 rdf:rest rdf:nil
87 N8766349b5f9247d4ad904f6cd5da10de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Drug Compounding
89 rdf:type schema:DefinedTerm
90 N88f6158a7fc64d2686ea966654bec91e schema:name Springer Nature
91 rdf:type schema:Organisation
92 N900a1daa55934d7db3826ec40105b4b0 rdf:first sg:person.0723171027.98
93 rdf:rest N219809cfd9584f3ea176508ac09d1d07
94 N98afceca1ac146a8992015c0a579a333 schema:name doi
95 schema:value 10.1007/978-1-4939-6445-1_22
96 rdf:type schema:PropertyValue
97 N9ec5dec4db544ebeaa17c48120547efc rdf:first Nbc32871aa370422a8eef5e30e296c7f7
98 rdf:rest rdf:nil
99 Nbc32871aa370422a8eef5e30e296c7f7 schema:familyName Fox
100 schema:givenName Christopher B.
101 rdf:type schema:Person
102 Nbcbc88d7f82146e19a57d87e9b35f75c schema:name pubmed_id
103 schema:value 27718203
104 rdf:type schema:PropertyValue
105 Nbf8fd9aab1fe42dd81a2cb604acb3ee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Vaccines
107 rdf:type schema:DefinedTerm
108 Nc461ff92885a4fb18be3d20682983756 schema:isbn 978-1-4939-6443-7
109 978-1-4939-6445-1
110 schema:name Vaccine Adjuvants
111 rdf:type schema:Book
112 Nffacd43b4f734883bcfb792cb232ba8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
116 schema:name Chemical Sciences
117 rdf:type schema:DefinedTerm
118 anzsrc-for:0399 schema:inDefinedTermSet anzsrc-for:
119 schema:name Other Chemical Sciences
120 rdf:type schema:DefinedTerm
121 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
122 schema:name Biological Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
125 schema:name Biochemistry and Cell Biology
126 rdf:type schema:DefinedTerm
127 sg:person.011224426621.24 schema:affiliation grid-institutes:None
128 schema:familyName To
129 schema:givenName Frederick
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011224426621.24
131 rdf:type schema:Person
132 sg:person.01322544210.31 schema:affiliation grid-institutes:None
133 schema:familyName Brookes
134 schema:givenName Roger H.
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322544210.31
136 rdf:type schema:Person
137 sg:person.01354732604.20 schema:affiliation grid-institutes:None
138 schema:familyName Rahman
139 schema:givenName Nausheen
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354732604.20
141 rdf:type schema:Person
142 sg:person.01372575534.26 schema:affiliation grid-institutes:None
143 schema:familyName Hakimi
144 schema:givenName Jalil
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372575534.26
146 rdf:type schema:Person
147 sg:person.0643657214.95 schema:affiliation grid-institutes:None
148 schema:familyName Aboutorabian
149 schema:givenName Sepideh
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643657214.95
151 rdf:type schema:Person
152 sg:person.0723171027.98 schema:affiliation grid-institutes:None
153 schema:familyName Ausar
154 schema:givenName Salvador F.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723171027.98
156 rdf:type schema:Person
157 grid-institutes:None schema:alternateName Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada
158 schema:name Bioprocess Research and Development, Sanofi Pasteur, 1755 Steeles Avenue West, M2R 3T4, Toronto, Canada
159 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...