Cleavable Linkers in Chemical Proteomics Applications View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2017

AUTHORS

Yinliang Yang , Marko Fonović , Steven H. L. Verhelst

ABSTRACT

The discovery of the protein targets of small molecule probes is a crucial aspect of activity-based protein profiling and chemical biology. Mass spectrometry is the primary method for target identification, and in the last decade, cleavable linkers have become a popular strategy to facilitate protein enrichment and identification. In this chapter, we provide an overview of cleavable linkers used in chemical proteomics approaches, discuss their different chemistries, and describe how they aid in protein identification. More... »

PAGES

185-203

Book

TITLE

Activity-Based Proteomics

ISBN

978-1-4939-6437-6
978-1-4939-6439-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-6439-0_14

DOI

http://dx.doi.org/10.1007/978-1-4939-6439-0_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046485447

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27778290


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