G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Alessandro Cannavo , Claudio de Lucia , Walter J. Koch

ABSTRACT

The superfamily of G-protein-coupled receptors (GPCRs), or seven transmembrane-spanning receptors (7TMRs), represents the largest family of membrane proteins that transduce cell signals via heterotrimeric G proteins from neurohormones, ions, and sensory stimuli to regulate virtually every aspect of mammalian physiology. In the normal and diseased heart, it is apparent that major players include the β-adrenergic receptors (βARs) and the angiotensin II type 1 receptors (AT1Rs). Their crucial role is reflected by the fact that, currently, they represent the direct targets of different approved cardiovascular drugs used in clinical practice. However, other “minor” receptors and their signaling pathways have been identified for roles that they exert on cardiac pathophysiology. GPCRs can, individually or collectively, regulate cardiac growth and function, including processes such as heart rate, contractility, and blood pressure, in response to catecholamines and other neurohormones. For these reasons, GPCRs are dynamically regulated to prevent overstimulation that could lead to cardiac diseases like heart failure (HF). This dampening process, known as desensitization, is initiated through GPCR phosphorylation by second-messenger kinases like protein kinase A (PKA) and PKC or the GPCR kinases (GRKs). PKA and PKC initiate heterologous desensitization, while GRKs initiate homologous desensitization, phosphorylating only agonist-occupied GPCRs. This GPCR regulation by GRKs induces recruitment and binding of β-arrestins that displace bound G proteins, therefore uncoupling receptors from their downstream signaling effectors. This process continues through β-arrestin-dependent internalization of receptors, that lead either to their degradation and downregulation or recycling (resensitization) to the membrane. Moreover, β-arrestin recruitment to GRK-phosphorylated receptors has been shown to lead to intracellular signaling, a process called G protein-dependent and independent signaling. Given their central role in cardiac physiology and in pathology, GPCRs are critical therapeutic targets in cardiac diseases and GRKs are emerging as innovative targets. More... »

PAGES

271-281

Book

TITLE

G Protein-Coupled Receptor Kinases

ISBN

978-1-4939-3796-7
978-1-4939-3798-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-3798-1_12

DOI

http://dx.doi.org/10.1007/978-1-4939-3798-1_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027072806


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Pharmacology, Center for Translational Medicine, School of Medicine, Temple University"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cannavo", 
        "givenName": "Alessandro", 
        "id": "sg:person.01211760131.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211760131.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Pharmacology, Center for Translational Medicine, School of Medicine, Temple University"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Lucia", 
        "givenName": "Claudio", 
        "id": "sg:person.01165357074.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165357074.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University", 
          "id": "https://www.grid.ac/institutes/grid.264727.2", 
          "name": [
            "Department of Pharmacology, Center for Translational Medicine, School of Medicine, Temple University"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koch", 
        "givenName": "Walter J.", 
        "id": "sg:person.0663235251.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663235251.68"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m707422200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000142396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.112.273367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002609514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.112.273367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002609514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.98.4.1607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003037643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000020014.14176.6d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003844816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.529347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004192413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.39.27351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009376457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.19.11272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009933326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-394440-5.00012-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011658201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000247932.71270.2c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012826518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000247932.71270.2c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012826518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.10.5839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013292594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r109.051847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013309396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3300605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013657997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3300605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013657997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110647200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014157571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.002659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014233636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.002659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014233636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0508-485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014289773", 
          "https://doi.org/10.1038/nm0508-485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.01061.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015026181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.107.133975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016385415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0409532102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016601741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.18.9954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017580222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1834556100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018969924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2004.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019423379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.168336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021545701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.168336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021545701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2006.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022064681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.015248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025076812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.015248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025076812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.114.300513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026230272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.114.300513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026230272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2013.00264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027028355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0803153105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027633952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.113.300308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027975563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.113.300308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027975563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.9.2797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028849842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-4975(00)01754-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029014377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.106.664862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031163594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5356.1552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031703820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.101.10.1130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032940651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvp086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034534186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvp086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034534186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2003.03942.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034836234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/377744a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035670321", 
          "https://doi.org/10.1038/377744a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1999.1179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035972960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2319-4170.113233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036508331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hh1901.098042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037715053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0062508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038199348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.87.2.454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038435833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.86.1.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039197989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.29.18180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039313651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00454-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040049645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.103.12.1649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041026883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041031427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-007-6016-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041511386", 
          "https://doi.org/10.1007/s10557-007-6016-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-007-6016-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041511386", 
          "https://doi.org/10.1007/s10557-007-6016-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.74.2.206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041817946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.112.007203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043072764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m708912200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043292864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamem.2007.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043485392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-201x.2003.01063.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043919031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.231233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045081707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.231233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045081707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0066234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046799031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00395-014-0456-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046911828", 
          "https://doi.org/10.1007/s00395-014-0456-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.110.067066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047513876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0057324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048492606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/dddt.s35905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048910385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7761854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049808188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2008.07.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049874837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.108.803999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049984492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.85.10.e44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050059144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1054-3589(10)59005-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050546588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.304475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050816206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.304475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050816206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m601327200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052270401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.221010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052647150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.221010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052647150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(99)00344-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054580622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cb3003013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055226232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1325672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062475373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2163110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062525124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/stke.2001.104.re15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062690239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070916059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.2001.281.6.h2490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074954289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078406900", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079518066", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082584089", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082788083", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082816760", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1997.273.2.h707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083138264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1998.275.4.h1298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083319421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1998.275.4.h1298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083319421"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016", 
    "datePublishedReg": "2016-01-01", 
    "description": "The superfamily of G-protein-coupled receptors (GPCRs), or seven transmembrane-spanning receptors (7TMRs), represents the largest family of membrane proteins that transduce cell signals via heterotrimeric G proteins from neurohormones, ions, and sensory stimuli to regulate virtually every aspect of mammalian physiology. In the normal and diseased heart, it is apparent that major players include the \u03b2-adrenergic receptors (\u03b2ARs) and the angiotensin II type 1 receptors (AT1Rs). Their crucial role is reflected by the fact that, currently, they represent the direct targets of different approved cardiovascular drugs used in clinical practice. However, other \u201cminor\u201d receptors and their signaling pathways have been identified for roles that they exert on cardiac pathophysiology. GPCRs can, individually or collectively, regulate cardiac growth and function, including processes such as heart rate, contractility, and blood pressure, in response to catecholamines and other neurohormones. For these reasons, GPCRs are dynamically regulated to prevent overstimulation that could lead to cardiac diseases like heart failure (HF). This dampening process, known as desensitization, is initiated through GPCR phosphorylation by second-messenger kinases like protein kinase A (PKA) and PKC or the GPCR kinases (GRKs). PKA and PKC initiate heterologous desensitization, while GRKs initiate homologous desensitization, phosphorylating only agonist-occupied GPCRs. This GPCR regulation by GRKs induces recruitment and binding of \u03b2-arrestins that displace bound G proteins, therefore uncoupling receptors from their downstream signaling effectors. This process continues through \u03b2-arrestin-dependent internalization of receptors, that lead either to their degradation and downregulation or recycling (resensitization) to the membrane. Moreover, \u03b2-arrestin recruitment to GRK-phosphorylated receptors has been shown to lead to intracellular signaling, a process called G protein-dependent and independent signaling. Given their central role in cardiac physiology and in pathology, GPCRs are critical therapeutic targets in cardiac diseases and GRKs are emerging as innovative targets.", 
    "editor": [
      {
        "familyName": "Gurevich", 
        "givenName": "Vsevolod V.", 
        "type": "Person"
      }, 
      {
        "familyName": "Gurevich", 
        "givenName": "Eugenia V.", 
        "type": "Person"
      }, 
      {
        "familyName": "Tesmer", 
        "givenName": "John J.G.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-1-4939-3798-1_12", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-1-4939-3796-7", 
        "978-1-4939-3798-1"
      ], 
      "name": "G Protein-Coupled Receptor Kinases", 
      "type": "Book"
    }, 
    "name": "G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation", 
    "pagination": "271-281", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-1-4939-3798-1_12"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "80f799673d8c81fa891787b8220726fbed44024c0579db884795742595e23bc4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027072806"
        ]
      }
    ], 
    "publisher": {
      "location": "New York, NY", 
      "name": "Springer New York", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-1-4939-3798-1_12", 
      "https://app.dimensions.ai/details/publication/pub.1027072806"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T12:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000288.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-1-4939-3798-1_12"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3798-1_12'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3798-1_12'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3798-1_12'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3798-1_12'


 

This table displays all metadata directly associated to this object as RDF triples.

328 TRIPLES      23 PREDICATES      107 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-1-4939-3798-1_12 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author N4a1552fa42ed4b9bba1f3d489b2bfc42
4 schema:citation sg:pub.10.1007/s00395-014-0456-3
5 sg:pub.10.1007/s10557-007-6016-4
6 sg:pub.10.1038/377744a0
7 sg:pub.10.1038/nm0508-485
8 https://app.dimensions.ai/details/publication/pub.1078406900
9 https://app.dimensions.ai/details/publication/pub.1079518066
10 https://app.dimensions.ai/details/publication/pub.1082584089
11 https://app.dimensions.ai/details/publication/pub.1082788083
12 https://app.dimensions.ai/details/publication/pub.1082816760
13 https://doi.org/10.1006/bbrc.1999.1179
14 https://doi.org/10.1016/b978-0-12-394440-5.00012-7
15 https://doi.org/10.1016/j.bbamem.2007.02.010
16 https://doi.org/10.1016/j.cardiores.2006.06.015
17 https://doi.org/10.1016/j.ejphar.2004.03.015
18 https://doi.org/10.1016/j.ejphar.2008.07.042
19 https://doi.org/10.1016/s0003-4975(00)01754-9
20 https://doi.org/10.1016/s0008-6363(99)00344-2
21 https://doi.org/10.1016/s0960-9822(02)00454-2
22 https://doi.org/10.1016/s1054-3589(10)59005-7
23 https://doi.org/10.1021/cb3003013
24 https://doi.org/10.1042/bj3300605
25 https://doi.org/10.1046/j.1365-201x.2003.01063.x
26 https://doi.org/10.1073/pnas.0409532102
27 https://doi.org/10.1073/pnas.0803153105
28 https://doi.org/10.1073/pnas.1834556100
29 https://doi.org/10.1073/pnas.83.9.2797
30 https://doi.org/10.1073/pnas.93.18.9954
31 https://doi.org/10.1073/pnas.98.4.1607
32 https://doi.org/10.1074/jbc.271.10.5839
33 https://doi.org/10.1074/jbc.271.19.11272
34 https://doi.org/10.1074/jbc.273.29.18180
35 https://doi.org/10.1074/jbc.274.39.27351
36 https://doi.org/10.1074/jbc.m110647200
37 https://doi.org/10.1074/jbc.m113.529347
38 https://doi.org/10.1074/jbc.m601327200
39 https://doi.org/10.1074/jbc.m707422200
40 https://doi.org/10.1074/jbc.m708912200
41 https://doi.org/10.1074/jbc.r109.051847
42 https://doi.org/10.1093/cvr/cvp086
43 https://doi.org/10.1093/eurheartj/ehr447
44 https://doi.org/10.1111/j.1440-1681.2003.03942.x
45 https://doi.org/10.1124/jpet.107.133975
46 https://doi.org/10.1124/mol.110.067066
47 https://doi.org/10.1124/pr.112.007203
48 https://doi.org/10.1126/science.1325672
49 https://doi.org/10.1126/science.2163110
50 https://doi.org/10.1126/science.279.5356.1552
51 https://doi.org/10.1126/science.7761854
52 https://doi.org/10.1126/stke.2001.104.re15
53 https://doi.org/10.1152/ajpheart.01061.2011
54 https://doi.org/10.1152/ajpheart.1997.273.2.h707
55 https://doi.org/10.1152/ajpheart.1998.275.4.h1298
56 https://doi.org/10.1152/ajpheart.2001.281.6.h2490
57 https://doi.org/10.1161/01.cir.0000020014.14176.6d
58 https://doi.org/10.1161/01.cir.101.10.1130
59 https://doi.org/10.1161/01.cir.103.12.1649
60 https://doi.org/10.1161/01.cir.87.2.454
61 https://doi.org/10.1161/01.res.0000247932.71270.2c
62 https://doi.org/10.1161/01.res.74.2.206
63 https://doi.org/10.1161/01.res.85.10.e44
64 https://doi.org/10.1161/01.res.86.1.43
65 https://doi.org/10.1161/circresaha.107.168336
66 https://doi.org/10.1161/circresaha.110.221010
67 https://doi.org/10.1161/circresaha.110.231233
68 https://doi.org/10.1161/circresaha.112.273367
69 https://doi.org/10.1161/circresaha.113.300308
70 https://doi.org/10.1161/circresaha.114.300513
71 https://doi.org/10.1161/circresaha.116.304475
72 https://doi.org/10.1161/circulationaha.106.664862
73 https://doi.org/10.1161/circulationaha.108.803999
74 https://doi.org/10.1161/circulationaha.113.002659
75 https://doi.org/10.1161/circulationaha.114.015248
76 https://doi.org/10.1161/hh1901.098042
77 https://doi.org/10.1371/journal.pone.0057324
78 https://doi.org/10.1371/journal.pone.0062508
79 https://doi.org/10.1371/journal.pone.0066234
80 https://doi.org/10.2147/dddt.s35905
81 https://doi.org/10.2741/3898
82 https://doi.org/10.3389/fphys.2013.00264
83 https://doi.org/10.4103/2319-4170.113233
84 schema:datePublished 2016
85 schema:datePublishedReg 2016-01-01
86 schema:description The superfamily of G-protein-coupled receptors (GPCRs), or seven transmembrane-spanning receptors (7TMRs), represents the largest family of membrane proteins that transduce cell signals via heterotrimeric G proteins from neurohormones, ions, and sensory stimuli to regulate virtually every aspect of mammalian physiology. In the normal and diseased heart, it is apparent that major players include the β-adrenergic receptors (βARs) and the angiotensin II type 1 receptors (AT1Rs). Their crucial role is reflected by the fact that, currently, they represent the direct targets of different approved cardiovascular drugs used in clinical practice. However, other “minor” receptors and their signaling pathways have been identified for roles that they exert on cardiac pathophysiology. GPCRs can, individually or collectively, regulate cardiac growth and function, including processes such as heart rate, contractility, and blood pressure, in response to catecholamines and other neurohormones. For these reasons, GPCRs are dynamically regulated to prevent overstimulation that could lead to cardiac diseases like heart failure (HF). This dampening process, known as desensitization, is initiated through GPCR phosphorylation by second-messenger kinases like protein kinase A (PKA) and PKC or the GPCR kinases (GRKs). PKA and PKC initiate heterologous desensitization, while GRKs initiate homologous desensitization, phosphorylating only agonist-occupied GPCRs. This GPCR regulation by GRKs induces recruitment and binding of β-arrestins that displace bound G proteins, therefore uncoupling receptors from their downstream signaling effectors. This process continues through β-arrestin-dependent internalization of receptors, that lead either to their degradation and downregulation or recycling (resensitization) to the membrane. Moreover, β-arrestin recruitment to GRK-phosphorylated receptors has been shown to lead to intracellular signaling, a process called G protein-dependent and independent signaling. Given their central role in cardiac physiology and in pathology, GPCRs are critical therapeutic targets in cardiac diseases and GRKs are emerging as innovative targets.
87 schema:editor Ne2377544596248d6b7fdd10f478ebb68
88 schema:genre chapter
89 schema:inLanguage en
90 schema:isAccessibleForFree false
91 schema:isPartOf Nb64ba45c1c314664bc0667db425a2502
92 schema:name G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation
93 schema:pagination 271-281
94 schema:productId N1589df1f11e7443c82ce9a97dab6905b
95 N1e5c69cb470f4fceb27bb4c42029a1ea
96 N7307a091bd7f42e7b8c9150ea4d5fe57
97 schema:publisher N5f1b7bb467c24bd59d36bca2b600d19f
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027072806
99 https://doi.org/10.1007/978-1-4939-3798-1_12
100 schema:sdDatePublished 2019-04-15T12:37
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher Ne63320a0688d42c69ff1a9536bc815a1
103 schema:url http://link.springer.com/10.1007/978-1-4939-3798-1_12
104 sgo:license sg:explorer/license/
105 sgo:sdDataset chapters
106 rdf:type schema:Chapter
107 N1589df1f11e7443c82ce9a97dab6905b schema:name dimensions_id
108 schema:value pub.1027072806
109 rdf:type schema:PropertyValue
110 N1a3ab834b03e41f294bf84cdcaaa7aef schema:familyName Gurevich
111 schema:givenName Eugenia V.
112 rdf:type schema:Person
113 N1e5c69cb470f4fceb27bb4c42029a1ea schema:name doi
114 schema:value 10.1007/978-1-4939-3798-1_12
115 rdf:type schema:PropertyValue
116 N48e63905eb074e86af92b27c74062833 rdf:first N1a3ab834b03e41f294bf84cdcaaa7aef
117 rdf:rest N7064f140226e4a0885829278e191d2a0
118 N4a1552fa42ed4b9bba1f3d489b2bfc42 rdf:first sg:person.01211760131.91
119 rdf:rest N4ff5d6461f8e4ab2a933d1c66bb62719
120 N4ff5d6461f8e4ab2a933d1c66bb62719 rdf:first sg:person.01165357074.27
121 rdf:rest Nf19f0d216a114b7ead7f8fb5d648605c
122 N5f1b7bb467c24bd59d36bca2b600d19f schema:location New York, NY
123 schema:name Springer New York
124 rdf:type schema:Organisation
125 N6a9a06968f174dd18069988cda8af1b8 schema:familyName Tesmer
126 schema:givenName John J.G.
127 rdf:type schema:Person
128 N7064f140226e4a0885829278e191d2a0 rdf:first N6a9a06968f174dd18069988cda8af1b8
129 rdf:rest rdf:nil
130 N7307a091bd7f42e7b8c9150ea4d5fe57 schema:name readcube_id
131 schema:value 80f799673d8c81fa891787b8220726fbed44024c0579db884795742595e23bc4
132 rdf:type schema:PropertyValue
133 Nb1aab702468e4de79d6bcb00437142bf schema:familyName Gurevich
134 schema:givenName Vsevolod V.
135 rdf:type schema:Person
136 Nb64ba45c1c314664bc0667db425a2502 schema:isbn 978-1-4939-3796-7
137 978-1-4939-3798-1
138 schema:name G Protein-Coupled Receptor Kinases
139 rdf:type schema:Book
140 Ne2377544596248d6b7fdd10f478ebb68 rdf:first Nb1aab702468e4de79d6bcb00437142bf
141 rdf:rest N48e63905eb074e86af92b27c74062833
142 Ne63320a0688d42c69ff1a9536bc815a1 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Nf19f0d216a114b7ead7f8fb5d648605c rdf:first sg:person.0663235251.68
145 rdf:rest rdf:nil
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
150 schema:name Pharmacology and Pharmaceutical Sciences
151 rdf:type schema:DefinedTerm
152 sg:person.01165357074.27 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
153 schema:familyName de Lucia
154 schema:givenName Claudio
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165357074.27
156 rdf:type schema:Person
157 sg:person.01211760131.91 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
158 schema:familyName Cannavo
159 schema:givenName Alessandro
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211760131.91
161 rdf:type schema:Person
162 sg:person.0663235251.68 schema:affiliation https://www.grid.ac/institutes/grid.264727.2
163 schema:familyName Koch
164 schema:givenName Walter J.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663235251.68
166 rdf:type schema:Person
167 sg:pub.10.1007/s00395-014-0456-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046911828
168 https://doi.org/10.1007/s00395-014-0456-3
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s10557-007-6016-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041511386
171 https://doi.org/10.1007/s10557-007-6016-4
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/377744a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035670321
174 https://doi.org/10.1038/377744a0
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/nm0508-485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014289773
177 https://doi.org/10.1038/nm0508-485
178 rdf:type schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1078406900 schema:CreativeWork
180 https://app.dimensions.ai/details/publication/pub.1079518066 schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1082584089 schema:CreativeWork
182 https://app.dimensions.ai/details/publication/pub.1082788083 schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1082816760 schema:CreativeWork
184 https://doi.org/10.1006/bbrc.1999.1179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035972960
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/b978-0-12-394440-5.00012-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011658201
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.bbamem.2007.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043485392
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.cardiores.2006.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022064681
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.ejphar.2004.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019423379
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.ejphar.2008.07.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049874837
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0003-4975(00)01754-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029014377
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0008-6363(99)00344-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580622
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s0960-9822(02)00454-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040049645
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s1054-3589(10)59005-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050546588
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1021/cb3003013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055226232
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1042/bj3300605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013657997
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1046/j.1365-201x.2003.01063.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043919031
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1073/pnas.0409532102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016601741
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1073/pnas.0803153105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027633952
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.1834556100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018969924
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1073/pnas.83.9.2797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028849842
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1073/pnas.93.18.9954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017580222
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1073/pnas.98.4.1607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003037643
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1074/jbc.271.10.5839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013292594
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1074/jbc.271.19.11272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009933326
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1074/jbc.273.29.18180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039313651
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1074/jbc.274.39.27351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009376457
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1074/jbc.m110647200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014157571
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1074/jbc.m113.529347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004192413
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1074/jbc.m601327200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052270401
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1074/jbc.m707422200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000142396
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1074/jbc.m708912200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043292864
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1074/jbc.r109.051847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013309396
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1093/cvr/cvp086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034534186
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/eurheartj/ehr447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041031427
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.1440-1681.2003.03942.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836234
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1124/jpet.107.133975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016385415
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1124/mol.110.067066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047513876
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1124/pr.112.007203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043072764
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1126/science.1325672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062475373
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1126/science.2163110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062525124
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1126/science.279.5356.1552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031703820
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1126/science.7761854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049808188
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/stke.2001.104.re15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062690239
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1152/ajpheart.01061.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015026181
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1152/ajpheart.1997.273.2.h707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083138264
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1152/ajpheart.1998.275.4.h1298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083319421
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1152/ajpheart.2001.281.6.h2490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074954289
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1161/01.cir.0000020014.14176.6d schema:sameAs https://app.dimensions.ai/details/publication/pub.1003844816
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1161/01.cir.101.10.1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032940651
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1161/01.cir.103.12.1649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041026883
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1161/01.cir.87.2.454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038435833
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1161/01.res.0000247932.71270.2c schema:sameAs https://app.dimensions.ai/details/publication/pub.1012826518
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1161/01.res.74.2.206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041817946
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1161/01.res.85.10.e44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050059144
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1161/01.res.86.1.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039197989
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1161/circresaha.107.168336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021545701
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1161/circresaha.110.221010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052647150
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1161/circresaha.110.231233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045081707
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1161/circresaha.112.273367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002609514
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1161/circresaha.113.300308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027975563
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1161/circresaha.114.300513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026230272
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1161/circresaha.116.304475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050816206
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1161/circulationaha.106.664862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031163594
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1161/circulationaha.108.803999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049984492
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1161/circulationaha.113.002659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014233636
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1161/circulationaha.114.015248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025076812
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1161/hh1901.098042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037715053
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1371/journal.pone.0057324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048492606
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1371/journal.pone.0062508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038199348
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1371/journal.pone.0066234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046799031
317 rdf:type schema:CreativeWork
318 https://doi.org/10.2147/dddt.s35905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048910385
319 rdf:type schema:CreativeWork
320 https://doi.org/10.2741/3898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070916059
321 rdf:type schema:CreativeWork
322 https://doi.org/10.3389/fphys.2013.00264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027028355
323 rdf:type schema:CreativeWork
324 https://doi.org/10.4103/2319-4170.113233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508331
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.264727.2 schema:alternateName Temple University
327 schema:name Department of Pharmacology, Center for Translational Medicine, School of Medicine, Temple University
328 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...