Best Practices in Manual Annotation with the Gene Ontology View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2017

AUTHORS

Sylvain Poux , Pascale Gaudet

ABSTRACT

The Gene Ontology (GO) is a framework designed to represent biological knowledge about gene products' biological roles and the cellular location in which they act. Biocuration is a complex process: the body of scientific literature is large and selection of appropriate GO terms can be challenging. Both these issues are compounded by the fact that our understanding of biology is still incomplete; hence it is important to appreciate that GO is inherently an evolving model. In this chapter, we describe how biocurators create GO annotations from experimental findings from research articles. We describe the current best practices for high-quality literature curation and how GO curators succeed in modeling biology using a relatively simple framework. We also highlight a number of difficulties when translating experimental assays into GO annotations. More... »

PAGES

41-54

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-3743-1_4

DOI

http://dx.doi.org/10.1007/978-1-4939-3743-1_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031500741

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27812934


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