The PI3K-AKT Pathway in Melanoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Alan E. Siroy , Michael A. Davies , Alexander J. Lazar

ABSTRACT

Numerous signaling pathways are involved in the molecular pathogenesis of melanoma. Two of the most prominent pathways include the RAS-RAF-MEK-ERK pathway and the PI3K-AKT pathway. While targeted inhibition of BRAF/MEK have resulted in improved survival in patients with BRAF V600-mutated melanoma, therapeutic resistance is often the end result. The PI3K-AKT pathway plays a significant role in BRAF-/MEK-inhibitor resistance in melanoma patients and may represent a crucial target for combination therapy. This chapter will describe the components of the PI3K-AKT pathway, highlight their role in cellular physiology and melanoma pathogenesis, and examine their potential for molecular-targeted therapy. More... »

PAGES

165-180

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  • Book

    TITLE

    Genetics of Melanoma

    ISBN

    978-1-4939-3552-9
    978-1-4939-3554-3

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_7

    DOI

    http://dx.doi.org/10.1007/978-1-4939-3554-3_7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048715092


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