Targeted Therapy in Melanoma View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Isabella C. Glitza , Dae Won Kim , Young Kwang Chae , Kevin B. Kim

ABSTRACT

Melanoma has the highest mutation rate of all common cancers, and genomic research has accelerated the development of multiple new targeted therapies. The most commonly found mutations in melanoma are BRAF, NRAS, and KIT, and this chapter provides a detailed overview of each gene, their association with clinical features, as well as currently approved and investigational targeted approaches for each of these mutations. Safety profiles and underlying mechanisms of resistance are presented. Lastly, GNAQ/GNA11 mutations, found in up to 80 % of uveal melanoma patients, are detailed, and new insights into the role of the PTEN/PI3K/AKT/mTOR pathway are discussed. More... »

PAGES

237-265

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