2016
AUTHORSIsabella C. Glitza , Dae Won Kim , Young Kwang Chae , Kevin B. Kim
ABSTRACTMelanoma has the highest mutation rate of all common cancers, and genomic research has accelerated the development of multiple new targeted therapies. The most commonly found mutations in melanoma are BRAF, NRAS, and KIT, and this chapter provides a detailed overview of each gene, their association with clinical features, as well as currently approved and investigational targeted approaches for each of these mutations. Safety profiles and underlying mechanisms of resistance are presented. Lastly, GNAQ/GNA11 mutations, found in up to 80 % of uveal melanoma patients, are detailed, and new insights into the role of the PTEN/PI3K/AKT/mTOR pathway are discussed. More... »
PAGES237-265
Genetics of Melanoma
ISBN
978-1-4939-3552-9
978-1-4939-3554-3
http://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11
DOIhttp://dx.doi.org/10.1007/978-1-4939-3554-3_11
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1012346495
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center"
],
"type": "Organization"
},
"familyName": "Glitza",
"givenName": "Isabella C.",
"id": "sg:person.0777200706.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777200706.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Moffitt Cancer Center",
"id": "https://www.grid.ac/institutes/grid.468198.a",
"name": [
"Moffitt Cancer Center"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Dae Won",
"id": "sg:person.01101353714.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101353714.41"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine Robert H. Lurie Comprehensive Cancer Center of Northwestern University"
],
"type": "Organization"
},
"familyName": "Chae",
"givenName": "Young Kwang",
"id": "sg:person.01321066127.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321066127.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "California Pacific Medical Center",
"id": "https://www.grid.ac/institutes/grid.17866.3e",
"name": [
"Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center",
"California Pacific Medical Center"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Kevin B.",
"id": "sg:person.07644075244.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07644075244.00"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/gcc.20785",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000219370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/gcc.20785",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000219370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.41.1660",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000408054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mrfmmm.2004.05.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000650966"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2004.09.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000818705"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/canjclin.54.3.131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001163810"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-06-0613",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002404348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.49.8691",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002601649"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003324113",
"https://doi.org/10.1038/nature03890"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003324113",
"https://doi.org/10.1038/nature03890"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003324113",
"https://doi.org/10.1038/nature03890"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1755-148x.2011.00867.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003711251"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(12)60868-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003772891"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/43474",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004390180",
"https://doi.org/10.1038/43474"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/43474",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004390180",
"https://doi.org/10.1038/43474"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2133.2010.10185.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004824673"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1517/13543784.2012.665872",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004957042"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005853584",
"https://doi.org/10.1038/sj.bjc.6603291"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005853584",
"https://doi.org/10.1038/sj.bjc.6603291"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09627",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005907434",
"https://doi.org/10.1038/nature09627"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1105358",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006141094"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-1920",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006389423"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2010.11.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006637390"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa050092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007050226"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa050092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007050226"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-012-2457-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007858751",
"https://doi.org/10.1245/s10434-012-2457-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2011.177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008185187",
"https://doi.org/10.1038/bjc.2011.177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1517/17425255.2013.794220",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008695726"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-10-2276",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008929876"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08833",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009288742",
"https://doi.org/10.1038/nature08833"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08833",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009288742",
"https://doi.org/10.1038/nature08833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/pcmr.12098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009454863"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-11-1491",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009764558"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m508361200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009896776"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m508361200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009896776"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.25320",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009929890"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.42.1529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010610844"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-10-2200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010952678"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-04-2423",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011149370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.27790",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011291001"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08314",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011492298",
"https://doi.org/10.1038/nature08314"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08314",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011492298",
"https://doi.org/10.1038/nature08314"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmc1202124",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011935177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-2214",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012328920"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1002011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012824919"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1586/era.12.124",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013152689"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.0707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013453815"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-1144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013477910"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0015588",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013952398"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-13-0827",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014164434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-04-1443",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014291431"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jmg.2006.043802",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014471925"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-05-2720",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015172163"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(12)60398-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015389206"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-10-2954",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015745271"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-004-4189-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015934344",
"https://doi.org/10.1007/s00018-004-4189-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1201881",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015964544",
"https://doi.org/10.1038/sj.onc.1201881"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1201881",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015964544",
"https://doi.org/10.1038/sj.onc.1201881"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-1024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016716683"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jmoldx.2012.10.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016875765"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2006.06.0483",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017094741"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.813200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017692427"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-6787",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018054908"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1167/iovs.11-7398",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018057403"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-04-1399",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018443756"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg1879",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018626271",
"https://doi.org/10.1038/nrg1879"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg1879",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018626271",
"https://doi.org/10.1038/nrg1879"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07586",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018711414",
"https://doi.org/10.1038/nature07586"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2004.06.054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018967115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-03-0406",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019166991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2004.01.185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019181879"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1046/j.1523-1747.2003.12559.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019818817",
"https://doi.org/10.1046/j.1523-1747.2003.12559.x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.356",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019872106",
"https://doi.org/10.1038/ng.356"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.356",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019872106",
"https://doi.org/10.1038/ng.356"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cmr.0000200488.77970.e3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020530348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cmr.0000200488.77970.e3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020530348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cmr.0000200488.77970.e3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020530348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cmr.0000200488.77970.e3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020530348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0035309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020566700"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10637-009-9376-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021055401",
"https://doi.org/10.1007/s10637-009-9376-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cmr.0000215035.38436.87",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021528220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cmr.0000215035.38436.87",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021528220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.cmr.0000215035.38436.87",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021528220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)80405-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021616886"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2012.11.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021630699"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3322/caac.21166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021817259"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1517/13543784.2013.748032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022211796"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1208958",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022455909"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-10-0646",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022611192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.35.5263",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022896731"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-4598-11-22",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023231797",
"https://doi.org/10.1186/1476-4598-11-22"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature00766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023536940",
"https://doi.org/10.1038/nature00766"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature00766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023536940",
"https://doi.org/10.1038/nature00766"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(13)70237-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024216844"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024663272",
"https://doi.org/10.1038/sj.bjc.6602529"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024663272",
"https://doi.org/10.1038/sj.bjc.6602529"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-12-0052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025268968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1071550",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025685567"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1755-148x.2011.00837.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026283675"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0955-0674(97)80061-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026339231"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6604637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026373294",
"https://doi.org/10.1038/sj.bjc.6604637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.14.415",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026497166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.32.4327",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027360666"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)81519-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027843076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10662",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028208693",
"https://doi.org/10.1038/nature10662"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35096061",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028410796",
"https://doi.org/10.1038/35096061"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35096061",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028410796",
"https://doi.org/10.1038/35096061"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2011.746",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028680620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1000584",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028808360"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10637-011-9763-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029174258",
"https://doi.org/10.1007/s10637-011-9763-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0994-15",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029407853",
"https://doi.org/10.1038/ng0994-15"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.44.7888",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029409381"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-011-1620-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030239972",
"https://doi.org/10.1007/s00280-011-1620-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(12)70539-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030867551"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1139/o04-130",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031538104"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.47.7836",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031794892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.26724",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031953930"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1167/iovs.07-0722",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032531602"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032620847",
"https://doi.org/10.1038/nature09454"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032620847",
"https://doi.org/10.1038/nature09454"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(00)80595-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032865792"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-1985",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033168397"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.semcdb.2004.01.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033280784"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.jid.5700311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033284499",
"https://doi.org/10.1038/sj.jid.5700311"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-11-2436",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033545395"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.15.7636",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034168619"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-11-3086",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034289813"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21834",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034695273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21834",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034695273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.43.5966",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035149915"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000265558",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035298896"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09626",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035733152",
"https://doi.org/10.1038/nature09626"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035969538",
"https://doi.org/10.1038/ng1054"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1054",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035969538",
"https://doi.org/10.1038/ng1054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1755-148x.2011.00873.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036293454"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1210093",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036427533"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1012863",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037192126"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.28306",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037251786"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-09-0459",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037490992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-06-1150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037998097"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.33.9275",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038427267"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-06-0614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038608923"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1008990107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039016844"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6604482",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039293072",
"https://doi.org/10.1038/sj.bjc.6604482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19840315)53:6<1299::aid-cncr2820530613>3.0.co;2-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039700006"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10555-005-1577-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039749569",
"https://doi.org/10.1007/s10555-005-1577-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1212704",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040020285"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-11-1875",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040107577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21265",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040207329"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21265",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040207329"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.33.2312",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040298667"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.25766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040402237"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2006.06.2984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041185282"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1103782",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041864150"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/378785a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042289302",
"https://doi.org/10.1038/378785a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-10-0902",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042988841"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bcp.2010.04.032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043338592"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0028973",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045497074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(12)70269-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045686462"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(12)70270-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045691543"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(12)70270-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045691543"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ctrv.2003.07.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046090478"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbamcr.2006.10.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046575357"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1587907",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046609566"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2011.257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046660763",
"https://doi.org/10.1038/bjc.2011.257"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203183",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046929263",
"https://doi.org/10.1038/sj.onc.1203183"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203183",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046929263",
"https://doi.org/10.1038/sj.onc.1203183"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-006-0323-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046945764",
"https://doi.org/10.1007/s00280-006-0323-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00280-006-0323-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046945764",
"https://doi.org/10.1007/s00280-006-0323-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2011.250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047080070",
"https://doi.org/10.1038/onc.2011.250"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-07-1440",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048145384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1755-148x.2008.00475.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048947620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.mct-11-0989",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050113307"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-2483",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050427305"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2006.03.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051144156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(13)70024-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051396936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(13)70024-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051396936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1112302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051449373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0005717",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051562220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1203421",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051983710"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2013.3620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052066779"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2013.3620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052066779"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1003466",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052212829"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1755-148x.2011.00950.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052447580"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052520154",
"https://doi.org/10.1038/ncb839"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb839",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052520154",
"https://doi.org/10.1038/ncb839"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-11-2488",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052732661"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.4956",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052792184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-09-1883",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052925566"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11183",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053677952",
"https://doi.org/10.1038/nature11183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1535-7163.targ-11-b243",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063227811"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ijo_00000277",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071518258"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/cc.21645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072296965"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/cc.9.8.11487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072301506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1999.17.7.2105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074549817"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1999.17.9.2745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074549906"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074673369",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074805946",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2001.19.15.3477",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074857559"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075208264",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075295415",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077223798",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.31.18_suppl.cra9003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083394087"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.29.15_suppl.3003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083947512"
],
"type": "CreativeWork"
}
],
"datePublished": "2016",
"datePublishedReg": "2016-01-01",
"description": "Melanoma has the highest mutation rate of all common cancers, and genomic research has accelerated the development of multiple new targeted therapies. The most commonly found mutations in melanoma are BRAF, NRAS, and KIT, and this chapter provides a detailed overview of each gene, their association with clinical features, as well as currently approved and investigational targeted approaches for each of these mutations. Safety profiles and underlying mechanisms of resistance are presented. Lastly, GNAQ/GNA11 mutations, found in up to 80 % of uveal melanoma patients, are detailed, and new insights into the role of the PTEN/PI3K/AKT/mTOR pathway are discussed.",
"editor": [
{
"familyName": "Torres-Cabala",
"givenName": "Carlos A.",
"type": "Person"
},
{
"familyName": "Curry",
"givenName": "Jonathan L.",
"type": "Person"
}
],
"genre": "chapter",
"id": "sg:pub.10.1007/978-1-4939-3554-3_11",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": {
"isbn": [
"978-1-4939-3552-9",
"978-1-4939-3554-3"
],
"name": "Genetics of Melanoma",
"type": "Book"
},
"name": "Targeted Therapy in Melanoma",
"pagination": "237-265",
"productId": [
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/978-1-4939-3554-3_11"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"3ad292b569ac16ee8d1647fd4605d35f4f6fc9723a9957153f4c139f539b834b"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1012346495"
]
}
],
"publisher": {
"location": "New York, NY",
"name": "Springer New York",
"type": "Organisation"
},
"sameAs": [
"https://doi.org/10.1007/978-1-4939-3554-3_11",
"https://app.dimensions.ai/details/publication/pub.1012346495"
],
"sdDataset": "chapters",
"sdDatePublished": "2019-04-15T10:40",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000285.jsonl",
"type": "Chapter",
"url": "http://link.springer.com/10.1007/978-1-4939-3554-3_11"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
This table displays all metadata directly associated to this object as RDF triples.
654 TRIPLES
23 PREDICATES
201 URIs
20 LITERALS
8 BLANK NODES