2016
AUTHORSIsabella C. Glitza , Dae Won Kim , Young Kwang Chae , Kevin B. Kim
ABSTRACTMelanoma has the highest mutation rate of all common cancers, and genomic research has accelerated the development of multiple new targeted therapies. The most commonly found mutations in melanoma are BRAF, NRAS, and KIT, and this chapter provides a detailed overview of each gene, their association with clinical features, as well as currently approved and investigational targeted approaches for each of these mutations. Safety profiles and underlying mechanisms of resistance are presented. Lastly, GNAQ/GNA11 mutations, found in up to 80 % of uveal melanoma patients, are detailed, and new insights into the role of the PTEN/PI3K/AKT/mTOR pathway are discussed. More... »
PAGES237-265
Genetics of Melanoma
ISBN
978-1-4939-3552-9
978-1-4939-3554-3
http://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11
DOIhttp://dx.doi.org/10.1007/978-1-4939-3554-3_11
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-3554-3_11'
This table displays all metadata directly associated to this object as RDF triples.
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