Development of Rabies Virus-Like Particles for Vaccine Applications: Production, Characterization, and Protection Studies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Diego Fontana , Marina Etcheverrigaray , Ricardo Kratje , Claudio Prieto

ABSTRACT

Rabies is a viral infection of the central nervous system for which vaccination is the only treatment possible. Besides preexposure, vaccination is highly recommended for people living in endemic areas, veterinarians, and laboratory workers. Our group has developed rabies virus-like particles (RV-VLPs) with immunogenic features expressed in mammalian cells for vaccine applications. In this chapter the methods to obtain and characterize a stable HEK293 cell line expressing RV-VLPs are detailed. Further, analytical ultracentrifugation steps to purify the obtained VLPs are developed, as well as western blot, dynamic light scattering, and immunogold electron microscopy to analyze the size, distribution, shape, and antigenic conformation of the purified particles. Finally, immunization protocols are described to study the immunogenicity of RV-VLPs. More... »

PAGES

155-66

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-3387-7_7

DOI

http://dx.doi.org/10.1007/978-1-4939-3387-7_7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000522983

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27076129


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