Induction of Human Regulatory T Cells with Bacterial Superantigens View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Stefano Caserta , Amanda L. Taylor , Nadia Terrazzini , Martin J. Llewelyn

ABSTRACT

Regulatory T cells (Tregs) that suppress the activation of immune effector cells limit immunopathology and are fast emerging as therapeutic targets for autoimmune and cancer disease. Tools enabling Treg in vitro-induction, expansion, and characterization and manipulation will help future clinical developments. In this chapter, we describe in detail how to use bacterial superantigens to induce human Tregs efficiently from peripheral blood mononuclear cells. How to assess human Treg phenotype and suppressive capacity are also described. Technical details, variations, and alternative experimental conditions are provided. More... »

PAGES

181-206

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-3344-0_16

DOI

http://dx.doi.org/10.1007/978-1-4939-3344-0_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031276200

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26676048


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