The Role of Genetics in the Development of Familial Nonmedullary Thyroid Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Andreas Moraitis , Constantine A. Stratakis

ABSTRACT

The incidence of familial nonmedullary thyroid cancer (FNMTC) is increasing, especially in children. Genetic predisposition clearly plays a role in FNMTC development as evident from syndromes like Carney complex (CNC) or Cowden’s disease (CD) where it frequently develops. However, genes as PRKAR1A or PTEN that are responsible for CNC or CD, respectively, are not frequently mutated in sporadic FNMTC or at least not as frequently as RET mutations are found in medullary thyroid cancer. This chapter focuses on the genetics and management of FNMTC and familial syndromes associated with thyroid cancer and aims at assisting the clinician in recognizing the association of genetic syndromes with FNMTC, as well as stressing the implications of genetic involvement in treatment. More... »

PAGES

43-70

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  • Book

    TITLE

    Thyroid Cancer

    ISBN

    978-1-4939-3312-9
    978-1-4939-3314-3

    From Grant

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-3314-3_5

    DOI

    http://dx.doi.org/10.1007/978-1-4939-3314-3_5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025390243


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