Posttranslational Modifications of TGF-β Receptors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Xiaohua Yan , Ye-Guang Chen

ABSTRACT

TGF-β is a prototype of the TGF-β cytokine superfamily and exerts multiple regulatory effects on cell activities. It signals through two types of membrane-bound serine/threonine kinase receptors. Upon TGF-β binding, the type II receptor TβRII recruits the type I receptor TβRI and form a functional heterocomplex. TβRII trans-phosphorylates the GS region of TβRI, thus triggering its kinase activity. Activated TβRI proceeds to activate downstream Smad2/3. Signal intensity and duration through the availability, activity and destiny of TGF-β receptors are finely controlled by multiple posttranslational modifications such as phosphorylation, ubiquitination, and neddylation. This chapter introduces methods for examination of these modifications of TGF-β receptors. More... »

PAGES

49-61

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-2966-5_3

    DOI

    http://dx.doi.org/10.1007/978-1-4939-2966-5_3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006468625

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26520117


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