Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2015

AUTHORS

Jenna J. Guthmiller , Ryan A. Zander , Noah S. Butler

ABSTRACT

Whole attenuated parasite vaccines designed to elicit immunity against the clinically silent preerythrocytic stage of Plasmodium infection represent the most efficacious experimental platforms currently in clinical trial. Studies in rodents and humans show that T cells mediate vaccine-induced protection. Thus, determining the quantitative and qualitative properties of these T cells remains a major research focus. Most rodent models of preerythrocytic anti-Plasmodium vaccination focus on circumsporozoite-specific CD8 T cell responses in BALB/c mice. However, CD4 T cells and non-circumsporozoite-specific CD8 T cells also significantly contribute to protection. Here we describe alternative approaches that enable detection and functional characterization of total CD8 and CD4 T cell responses induced by preerythrocytic vaccination in mice. These flow cytometry-based approaches rely on monitoring the modulation of expressed integrins and co-receptors on the surface of T cells in vaccinated mice. The approaches enable direct determination of the magnitude, kinetics, distribution, phenotype, and functional features of T cell responses induced by infection or whole-parasite vaccination using any mouse-parasite species combination. More... »

PAGES

19-37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-2815-6_2

DOI

http://dx.doi.org/10.1007/978-1-4939-2815-6_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048303351

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26450376


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