Pharmacology and Clinical Development of New Molecularly Targeted Agents View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Elisa Giovannetti , Elena Galvani

ABSTRACT

Conventional chemotherapy regimens have limited impact against most solid tumors. Recent advances in our understanding of the molecular basis of cancer have enabled the development of new, rationally designed, molecularly targeted antitumor agents. These agents interact with receptors, ligands, signaling molecules, or genes that play a pivotal role in tumor transformation and growth, and they can inhibit tumor cell proliferation, induce programmed cell death, inhibit angiogenesis, or enhance antitumor immune response. The present chapter deals with the pharmacology of the most promising new molecularly targeted drugs for the treatment of solid tumors, such as drugs targeting the epidermal growth factor receptor (EGFR), which are playing a central role in advancing cancer research, treatment, and patient outcome over the last several years. For regulatory reasons, these agents are first evaluated in advanced/metastatic tumors, wherein they might prolong survival. However, their use in the adjuvant setting may also contribute to curative therapy. Nevertheless, the use of these agents must be optimized, according to several pharmacodynamics, pharmacokinetics, and pharmacogenetics issues. A major challenge is the proper identification of the subgroups of disease and patients who will truly benefit from these treatments. Ideally, convenient and minimally invasive tests to decipher biomarkers of chemosensitivity and/or resistance, which might be applied to the patient before and during treatment, should be developed alongside the development of the associated molecularly targeted agent. More... »

PAGES

9-29

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  • Book

    TITLE

    Targeted Therapies for Solid Tumors

    ISBN

    978-1-4939-2046-4
    978-1-4939-2047-1

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-2047-1_3

    DOI

    http://dx.doi.org/10.1007/978-1-4939-2047-1_3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034375836


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