Intraocular Tumors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Irene Scheimberg , M. Beth McCarville , Philip Luthert

ABSTRACT

Intraocular tumors of childhood are rare but have great clinical importance. The commonest pediatric intraocular tumor, the retinoblastoma, has provided pivotal insights into our understanding of tumor genesis. Retinoblastoma arises in the context of multiple genetic abnormalities, including two “hits” to the RB1 gene. In inherited cases, one of these hits is carried in the germ line; such patients often have multiple tumors. Correct handling of the enucleated eye is important in providing optimal information for further management. Massive choroidal involvement and extension into the optic nerve head, especially to the surgical resection margin in the case of the latter, are adverse prognostic features. Other intraocular tumors of childhood such as astrocytic hamartoma and medulloepithelioma are even rarer than retinoblastoma but should be considered in the differential diagnosis. More... »

PAGES

383-398

Book

TITLE

Pediatric Malignancies: Pathology and Imaging

ISBN

978-1-4939-1728-0
978-1-4939-1729-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-1729-7_14

DOI

http://dx.doi.org/10.1007/978-1-4939-1729-7_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011986659


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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