Quantitative Analysis of Chromosome Localization in the Nucleus View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014-10-01

AUTHORS

Sandeep Chakraborty , Ishita Mehta , Mugdha Kulashreshtha , B. J. Rao

ABSTRACT

The spatial organization of the genome within the interphase nucleus is important for mediating genome functions. The radial organization of chromosome territories has been studied traditionally using two-dimensional fluorescence in situ hybridization (FISH) using labeled whole chromosome probes. Information from 2D-FISH images is analyzed quantitatively and is depicted in the form of the spatial distribution of chromosomes territories. However, to the best of our knowledge no open-access tools are available to delineate the position of chromosome territories from 2D-FISH images. In this chapter we present a methodology termed Image Analysis of Chromosomes for computing their localization (IMACULAT). IMACULAT is an open-access, automated tool that partitions the cell nucleus into shells of equal area or volume and computes the spatial distribution of chromosome territories. More... »

PAGES

223-233

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-1680-1_17

DOI

http://dx.doi.org/10.1007/978-1-4939-1680-1_17

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020812168

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25311133


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