Dynamic Analysis of CO2 Labeling and Cell Respiration Using Membrane-Inlet Mass Spectrometry View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Tae Hoon Yang

ABSTRACT

Here, we introduce a mass spectrometry-based analytical method and relevant technical details for dynamic cell respiration and CO2 labeling analysis. Such measurements can be utilized as additional information and constraints for model-based (13)C metabolic flux analysis. Dissolved dynamics of oxygen consumption and CO2 mass isotopomer evolution from (13)C-labeled tracer substrates through different cellular processes can be precisely measured on-line using a miniaturized reactor system equipped with a membrane-inlet mass spectrometer. The corresponding specific rates of physiologically relevant gases and CO2 mass isotopomers can be quantified within a short-term range based on the liquid-phase dynamics of dissolved fermentation gases. More... »

PAGES

175-94

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-1-4939-1170-7_11

DOI

http://dx.doi.org/10.1007/978-1-4939-1170-7_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018465500

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25178791


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