Hepatic Encephalopathy: A Primary Neurogliopathy View Full Text


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Chapter Info

DATE

2014

AUTHORS

Sharon DeMorrow , Roger F Butterworth

ABSTRACT

Hepatic encephalopathy (HE) and brain edema are serious central nervous complications of both acute and chronic liver failure. HE starts as a neuropsychiatric syndrome beginning with changes in personality and sleep disturbances progressing through cognitive dysfunction and motor symptoms to stupor and coma. In acute liver failure (ALF) progression may be very rapid, sometimes of the order of days (Butterworth and Vaquero, The liver; biology and pathobiology, pp. 600–617, 2009). Since the appearance of overt signs of encephalopathy in liver failure generally heralds a poor prognosis with a significant impact on clinical management options, on liver transplant outcome and on health-related quality of life, rational effective therapies are urgently required. Such therapies require knowledge of the precise mechanisms implicated in the pathogenesis of HE. More... »

PAGES

351-372

References to SciGraph publications

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  • Book

    TITLE

    Pathological Potential of Neuroglia

    ISBN

    978-1-4939-0973-5
    978-1-4939-0974-2

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-0974-2_15

    DOI

    http://dx.doi.org/10.1007/978-1-4939-0974-2_15

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051601467


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