The Human Kidney at Birth: Structure and Function in Transition View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Robert L. Chevalier , Jennifer R. Charlton

ABSTRACT

In the normal transition of the term infant from fetal to extrauterine life, nephrogenesis is complete and the number of functioning nephrons is not reduced. However, the range of nephron number in the human population varies by over tenfold, a function of normal inter-individual variation. Nephrogenesis may be impaired by fetal stress (malnutrition, ischemia, hypoxia, toxins, infection), maldevelopment, or preterm birth. Compensatory growth of remaining nephrons is maladaptive, leading to decreasing nephron function in adulthood. Serum creatinine concentration is a poor predictor of renal development or injury, and more accurate biomarkers are desperately needed. Contrast-enhanced magnetic resonance imaging is currently being developed to permit the identification of glomeruli in vivo, permitting serial measurement of glomerular number and size. Improved management of renal disease will depend on elucidation of factors mediating or modulating nephrogenesis and nephron loss, and on better tracking of individual nephrons throughout life. More... »

PAGES

49-58

References to SciGraph publications

  • 2012-08. Evolution of the urinary proteome during human renal development and maturation: variations with gestational and postnatal age in PEDIATRIC RESEARCH
  • 2003-06. Glomerular number and size in autopsy kidneys: The relationship to birth weight in KIDNEY INTERNATIONAL
  • 2008-02. Histochemical and immunohistochemical study of the glomerular development in human fetuses in PEDIATRIC NEPHROLOGY
  • 1998-10. Contribution of tubular injury to loss of remnant kidney function in KIDNEY INTERNATIONAL
  • 2013-02. Chronic kidney disease following acute kidney injury—risk and outcomes in NATURE REVIEWS NEPHROLOGY
  • 2009. Embryology in PEDIATRIC NEPHROLOGY
  • 2012-12. Predicting the outcome of chronic kidney disease by the estimated nephron number: The rationale and design of PRONEP, a prospective, multicenter, observational cohort study in BMC NEPHROLOGY
  • 2012-11. Congenital urinary tract obstruction: defining markers of developmental kidney injury in PEDIATRIC RESEARCH
  • 2009-01. Human renal function maturation: a quantitative description using weight and postmenstrual age in PEDIATRIC NEPHROLOGY
  • 2007-11. CD24 is a marker of exosomes secreted into urine and amniotic fluid in KIDNEY INTERNATIONAL
  • 2004-02. Histomorphometric Analysis of Postnatal Glomerulogenesis in Extremely Preterm Infants in PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
  • 2002-07. Experimental models of fetal obstructive nephropathy in PEDIATRIC NEPHROLOGY
  • 2011-09. Human nephron number: implications for health and disease in PEDIATRIC NEPHROLOGY
  • Book

    TITLE

    Kidney Development in Renal Pathology

    ISBN

    978-1-4939-0946-9
    978-1-4939-0947-6

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-0947-6_5

    DOI

    http://dx.doi.org/10.1007/978-1-4939-0947-6_5

    DIMENSIONS

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