Transcriptional Regulation in Adipogenesis Through PPARγ-Dependent and -Independent Mechanisms by Prostaglandins View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Ko Fujimori , Yoshihiro Urade

ABSTRACT

Adipogenesis is controlled by complex mechanisms, and transcription factors are involved in its regulation. PPARγ is a ligand-dependent transcription factor and the most important one for adipogenesis. Although prostaglandin (PG) D2 metabolites have been reported as being the ligands of PPARγ, the endogenous PPARγ ligand in adipocytes remains unclear. Here, we show the methods for the general analysis of adipocyte differentiation and the protocols for promoter analysis, fluorescence EMSA, and chromatin immunoprecipitation assay for the transcriptional regulation of the SREBP-1c-activated lipocalin-type PGD synthase gene in adipocytes. Moreover, we describe that PGD2 and its metabolites are involved in the regulation of adipogenesis through PPARγ-dependent and -independent mechanisms. More... »

PAGES

177-96

References to SciGraph publications

  • 2011-11. Forming functional fat: a growing understanding of adipocyte differentiation in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-0805-9_15

    DOI

    http://dx.doi.org/10.1007/978-1-4939-0805-9_15

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026114578

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24927844


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