Genomic Applications in Colorectal and Pancreatic Tumors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Andreas Jung , Ralph Hruban

ABSTRACT

Colorectal cancer is one of the most common tumors in the Western world. Prior groundbreaking findings based on meticulous single gene analysis of colorectal tumors elucidated the progression from adenoma to invasive carcinoma in a multistep process driven by the accumulation of mutations in tumor suppressor genes (APC, p53, SMAD4) and oncogenes (KRAS). More recent high-throughput molecular genomic techniques confirmed the multistep model in the majority of sporadic colorectal cancers whereas smaller subgroup develop via different route, mostly initiated by a mutation in the BRAF oncogene, that results in oncogene-induced senescence (OIS) and the development of the gene methylator phenotype CIMP (CpG island methylator phenotype). Next-generation sequencing enables a more robust molecular classification of colorectal cancer, as well as pancreatic cancer. As a better understanding of the genetic alterations in pancreatic cancer emerges, it is becoming clear that a new molecular-based classification is possible. This classification would complement the morphologic classification system that has been developed and tested and integrates morphology and molecular findings into a cohesive system with prognostic and therapeutic implications. More... »

PAGES

415-434

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  • Book

    TITLE

    Genomic Applications in Pathology

    ISBN

    978-1-4939-0726-7
    978-1-4939-0727-4

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-1-4939-0727-4_25

    DOI

    http://dx.doi.org/10.1007/978-1-4939-0727-4_25

    DIMENSIONS

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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-0727-4_25'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-0727-4_25'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-0727-4_25'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-1-4939-0727-4_25'


     

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